The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: ENY2/SUS1

Export of messenger RNA (mRNA) from the nucleus to the cytoplasm is a critical step in the gene expression pathway of eukaryotic cells. In mammals, the TREX-2 complex links transcription/processing with nuclear mRNA export. Mammalian TREX-2 is based on a germinal-centre associated nuclear protein (GANP) scaffold to which ENY2, PCID2 and centrins bind PMID:22307388. ENY2 is a small transcription factor which is conserved from protozoa to humans PMID:11438676. In insects it is known as the enhancer of yellow 2 transcription factor (EnY2), but in other organisms is known as transcription and mRNA export factor SUS1 or ENY2. It is involved in mRNA export coupled transcription activation by association with both the TREX-2 complex and the transcription regulatory histone acetylation complex SAGA PMID:14718168,PMID:21746879,PMID:18923079,PMID:18034162. This entry represents ENY2 which is made up of 5 alpha-helices separated by hinge regions, arranged into an anti-parallel hairpin PMID:22307388.

GO Diversity

Unique GO annotations
37 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
872 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 42
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 17
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 15
Unique EC:
Unique GO: 37
Unique Species: 872