The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 66: Troponin C, slow skeletal and cardiac muscles

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
452 A0A087QT96 (/ISS) A0A087QT96 (/ISS) A0A087QT96 (/ISS) A0A087QT96 (/ISS) A0A087QT96 (/ISS) A0A087QT96 (/ISS) A0A087QT96 (/ISS) A0A087QT96 (/ISS) A0A087QT96 (/ISS) A0A087QT96 (/ISS)
(442 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
34 A0A060XPN3 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA)
(24 more)
Troponin I binding GO:0031013
Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex.
17 P63315 (/IPI) P63315 (/IPI) P63315 (/IPI) P63315 (/IPI) P63315 (/IPI) P63315 (/IPI) P63315 (/IPI) P63315 (/IPI) P63315 (/IPI) P63315 (/IPI)
(7 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
14 P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO)
(4 more)
Troponin I binding GO:0031013
Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex.
14 P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO)
(4 more)
Troponin T binding GO:0031014
Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex.
14 P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO)
(4 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
14 P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO)
(4 more)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
14 P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO)
(4 more)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
14 P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA)
(4 more)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
10 P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P63316 (/IPI) P63316 (/IPI) P63316 (/IPI) P63316 (/IPI) P63316 (/IPI) P63316 (/IPI) P63316 (/IPI)
Troponin I binding GO:0031013
Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex.
7 P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA)
Troponin T binding GO:0031014
Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex.
7 P63316 (/IPI) P63316 (/IPI) P63316 (/IPI) P63316 (/IPI) P63316 (/IPI) P63316 (/IPI) P63316 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
7 P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
7 P63316 (/IPI) P63316 (/IPI) P63316 (/IPI) P63316 (/IPI) P63316 (/IPI) P63316 (/IPI) P63316 (/IPI)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
7 P63316 (/ISS) P63316 (/ISS) P63316 (/ISS) P63316 (/ISS) P63316 (/ISS) P63316 (/ISS) P63316 (/ISS)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
26 P63316 (/IMP) P63316 (/IMP) P63316 (/IMP) P63316 (/IMP) P63316 (/IMP) P63316 (/IMP) P63316 (/IMP) Q4PP99 (/IMP) Q4PP99 (/IMP) Q4PP99 (/IMP)
(16 more)
Diaphragm contraction GO:0002086
A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange.
14 Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA)
(4 more)
Diaphragm contraction GO:0002086
A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange.
14 P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO)
(4 more)
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
14 P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO)
(4 more)
Response to metal ion GO:0010038
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
14 Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA)
(4 more)
Response to metal ion GO:0010038
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
14 P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO)
(4 more)
Transition between fast and slow fiber GO:0014883
The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation.
14 P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA)
(4 more)
Regulation of muscle filament sliding speed GO:0032972
Any process that modulates the velocity of muscle filament sliding.
14 P19123 (/IMP) P19123 (/IMP) P19123 (/IMP) P19123 (/IMP) P19123 (/IMP) P19123 (/IMP) P19123 (/IMP) P19123 (/IMP) P19123 (/IMP) P19123 (/IMP)
(4 more)
Regulation of ATPase activity GO:0043462
Any process that modulates the rate of ATP hydrolysis by an ATPase.
14 P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA) P19123 (/IDA)
(4 more)
Ventricular cardiac muscle tissue morphogenesis GO:0055010
The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.
14 P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO)
(4 more)
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
14 P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO)
(4 more)
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
7 P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA)
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
7 P63316 (/TAS) P63316 (/TAS) P63316 (/TAS) P63316 (/TAS) P63316 (/TAS) P63316 (/TAS) P63316 (/TAS)
Muscle filament sliding GO:0030049
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
7 P63316 (/TAS) P63316 (/TAS) P63316 (/TAS) P63316 (/TAS) P63316 (/TAS) P63316 (/TAS) P63316 (/TAS)
Regulation of muscle filament sliding speed GO:0032972
Any process that modulates the velocity of muscle filament sliding.
7 P63316 (/ISS) P63316 (/ISS) P63316 (/ISS) P63316 (/ISS) P63316 (/ISS) P63316 (/ISS) P63316 (/ISS)
Regulation of ATPase activity GO:0043462
Any process that modulates the rate of ATP hydrolysis by an ATPase.
7 P63316 (/ISS) P63316 (/ISS) P63316 (/ISS) P63316 (/ISS) P63316 (/ISS) P63316 (/ISS) P63316 (/ISS)
Ventricular cardiac muscle tissue morphogenesis GO:0055010
The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.
7 P63316 (/IMP) P63316 (/IMP) P63316 (/IMP) P63316 (/IMP) P63316 (/IMP) P63316 (/IMP) P63316 (/IMP)
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
7 P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA)
Cardiac ventricle development GO:0003231
The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
2 Q5XJB2 (/IMP) Q800V7 (/IMP)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
2 Q5XJB2 (/IDA) Q800V7 (/IDA)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cardiac Troponin complex GO:1990584
A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction.
17 P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA)
(7 more)
Troponin complex GO:0005861
A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.
14 P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO)
(4 more)
Contractile fiber GO:0043292
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
14 Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA) Q4PP99 (/IDA)
(4 more)
Contractile fiber GO:0043292
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
14 P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO)
(4 more)
Cardiac Troponin complex GO:1990584
A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction.
14 P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO) P19123 (/ISO)
(4 more)
Cardiac myofibril GO:0097512
A cardiac myofibril is a myofibril specific to cardiac muscle cells.
10 P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA) P63315 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 P63316 (/TAS) P63316 (/TAS) P63316 (/TAS) P63316 (/TAS) P63316 (/TAS) P63316 (/TAS) P63316 (/TAS)
Troponin complex GO:0005861
A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.
7 P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA) P63316 (/IDA)
Myofilament GO:0036379
Any of the smallest contractile units of a myofibril (striated muscle fiber).
3 A0A060XPN3 (/IDA) Q7ZZB9 (/IDA) Q7ZZB9 (/IDA)