The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 46: intersectin-1 isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 M9ND00 (/IPI) M9PBF6 (/IPI) M9PDC7 (/IPI) O61618 (/IPI) O61639 (/IPI) Q15811 (/IPI) Q1WWC9 (/IPI) Q8INU2 (/IPI) Q9NZM3 (/IPI) Q9VIF7 (/IPI)
(3 more)
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
1 Q9NZM3 (/TAS)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q15811 (/NAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q15811 (/NAS)
Kinase activator activity GO:0019209
Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 Q9Z0R4 (/IDA)
Molecular adaptor activity GO:0060090
The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 Q15811 (/IDA)
Molecular adaptor activity GO:0060090
The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 Q9Z0R4 (/ISO)
Proline-rich region binding GO:0070064
Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.
1 Q15811 (/IPI)
Proline-rich region binding GO:0070064
Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.
1 Q9Z0R4 (/ISO)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Synaptic vesicle endocytosis GO:0048488
A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
9 M9ND00 (/IMP) M9PBF6 (/IMP) M9PDC7 (/IMP) O61618 (/IMP) O61639 (/IMP) Q1WWC9 (/IMP) Q8INU2 (/IMP) Q9VIF7 (/IMP) Q9Z0R4 (/IMP)
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
8 M9ND00 (/IMP) M9PBF6 (/IMP) M9PDC7 (/IMP) O61618 (/IMP) O61639 (/IMP) Q1WWC9 (/IMP) Q8INU2 (/IMP) Q9VIF7 (/IMP)
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
8 M9ND00 (/IMP) M9PBF6 (/IMP) M9PDC7 (/IMP) O61618 (/IMP) O61639 (/IMP) Q1WWC9 (/IMP) Q8INU2 (/IMP) Q9VIF7 (/IMP)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
8 M9ND00 (/IDA) M9PBF6 (/IDA) M9PDC7 (/IDA) O61618 (/IDA) O61639 (/IDA) Q1WWC9 (/IDA) Q8INU2 (/IDA) Q9VIF7 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 Q15811 (/TAS)
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
1 Q9Z0R4 (/IDA)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 Q9WVE9 (/IEP)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
1 Q15811 (/IMP)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
1 Q9Z0R4 (/ISO)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q15811 (/TAS)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 Q9Z0R4 (/IMP)
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
1 M9ND00 (/IMP)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
1 Q15811 (/TAS)
Synaptic vesicle endocytosis GO:0048488
A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
1 Q9Z0R4 (/IDA)
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
1 Q15811 (/TAS)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 Q9Z0R4 (/IDA)
Positive regulation of growth hormone secretion GO:0060124
Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell.
1 Q9WVE9 (/IMP)
Positive regulation of growth hormone secretion GO:0060124
Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell.
1 Q9Z0R4 (/ISO)
Positive regulation of dendritic spine development GO:0060999
Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
1 Q9WVE9 (/IMP)
Positive regulation of dendritic spine development GO:0060999
Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
1 Q9Z0R4 (/ISO)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
1 Q15811 (/TAS)
Clathrin-dependent synaptic vesicle endocytosis GO:0150007
Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds.
1 M9ND00 (/IMP)
Bulk synaptic vesicle endocytosis GO:0150008
Endocytosis of large regions of presynaptic membrane after intense stimulation-mediated fusion of multiple synaptic vesicles. Bulk endocytosis is triggered by high loads of membrane addition through exocytosis of synaptic vesicles and elevated concentration of calcium in the presynapse.
1 M9ND00 (/IMP)
Positive regulation of dendrite extension GO:1903861
Any process that activates or increases the frequency, rate or extent of dendrite extension.
1 Q9NZM3 (/IDA)
Positive regulation of dendrite extension GO:1903861
Any process that activates or increases the frequency, rate or extent of dendrite extension.
1 Q9Z0R6 (/ISO)
Regulation of modification of postsynaptic actin cytoskeleton GO:1905274
Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton.
1 Q9WVE9 (/IDA)
Regulation of modification of postsynaptic actin cytoskeleton GO:1905274
Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton.
1 Q9WVE9 (/IMP)
Regulation of modification of postsynaptic actin cytoskeleton GO:1905274
Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton.
1 Q9Z0R4 (/ISO)
Positive regulation of caveolin-mediated endocytosis GO:2001288
Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis.
1 Q9WVE9 (/IMP)
Positive regulation of caveolin-mediated endocytosis GO:2001288
Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis.
1 Q9Z0R4 (/ISO)

There are 33 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 M9ND00 (/IDA) M9PBF6 (/IDA) M9PDC7 (/IDA) O61618 (/IDA) O61639 (/IDA) Q1WWC9 (/IDA) Q8INU2 (/IDA) Q9VIF7 (/IDA)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
8 M9ND00 (/IDA) M9PBF6 (/IDA) M9PDC7 (/IDA) O61618 (/IDA) O61639 (/IDA) Q1WWC9 (/IDA) Q8INU2 (/IDA) Q9VIF7 (/IDA)
Apical cortex GO:0045179
The region that lies just beneath the plasma membrane on the apical edge of a cell.
8 M9ND00 (/IDA) M9PBF6 (/IDA) M9PDC7 (/IDA) O61618 (/IDA) O61639 (/IDA) Q1WWC9 (/IDA) Q8INU2 (/IDA) Q9VIF7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q15811 (/TAS) Q9Z0R4 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q15811 (/IDA) Q9WVE9 (/IDA)
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
2 Q15811 (/IDA) Q9WVE9 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q6GMY7 (/HDA) Q9NZM3 (/HDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 Q9Z0R4 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9Z0R4 (/ISO)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q9NZM3 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q9Z0R6 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9Z0R4 (/ISO)
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
1 Q9Z0R4 (/ISO)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q9Z0R4 (/IDA)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
1 Q9Z0R4 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9WVE9 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9Z0R4 (/ISO)
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
1 Q9WVE9 (/HDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 Q9WVE9 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 Q9Z0R4 (/ISO)
Calyx of Held GO:0044305
The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system.
1 Q9Z0R4 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q9WVE9 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q9Z0R4 (/ISO)
Apical dendrite GO:0097440
A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon.
1 Q9WVE9 (/IDA)
Apical dendrite GO:0097440
A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon.
1 Q9Z0R4 (/ISO)
Intracellular vesicle GO:0097708
Any vesicle that is part of the intracellular region.
1 Q9WVE9 (/IDA)
Intracellular vesicle GO:0097708
Any vesicle that is part of the intracellular region.
1 Q9Z0R4 (/ISO)
Presynaptic endocytic zone GO:0098833
A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity.
1 Q9Z0R4 (/IDA)
Postsynaptic actin cytoskeleton GO:0098871
The actin cytoskeleton that is part of a postsynapse
1 Q9WVE9 (/IDA)
Postsynaptic actin cytoskeleton GO:0098871
The actin cytoskeleton that is part of a postsynapse
1 Q9Z0R4 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q9WVE9 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q9WVE9 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q9Z0R4 (/ISO)