The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 344: Protein S100-A8

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P05109 (/IPI) P05109 (/IPI) P05109 (/IPI)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Toll-like receptor 4 binding GO:0035662
Interacting selectively and non-covalently with a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Arachidonic acid binding GO:0050544
Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
RAGE receptor binding GO:0050786
Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)

There are 47 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Leukocyte migration involved in inflammatory response GO:0002523
The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.
7 P27005 (/ISS) P27005 (/ISS) P28782 (/ISS) P28782 (/ISS) P28782 (/ISS) P28782 (/ISS) P50115 (/ISS)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
7 P27005 (/ISS) P27005 (/ISS) P28782 (/ISS) P28782 (/ISS) P28782 (/ISS) P28782 (/ISS) P50115 (/ISS)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
7 P27005 (/ISS) P27005 (/ISS) P28782 (/ISS) P28782 (/ISS) P28782 (/ISS) P28782 (/ISS) P50115 (/ISS)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
7 P27005 (/ISS) P27005 (/ISS) P28782 (/ISS) P28782 (/ISS) P28782 (/ISS) P28782 (/ISS) P50115 (/ISS)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
7 P27005 (/ISS) P27005 (/ISS) P28782 (/ISS) P28782 (/ISS) P28782 (/ISS) P28782 (/ISS) P50115 (/ISS)
Neutrophil aggregation GO:0070488
The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules.
7 P27005 (/ISS) P27005 (/ISS) P28782 (/ISS) P28782 (/ISS) P28782 (/ISS) P28782 (/ISS) P50115 (/ISS)
Positive regulation of intrinsic apoptotic signaling pathway GO:2001244
Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.
7 P27005 (/ISS) P27005 (/ISS) P28782 (/ISS) P28782 (/ISS) P28782 (/ISS) P28782 (/ISS) P50115 (/ISS)
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Toll-like receptor signaling pathway GO:0002224
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Leukocyte migration involved in inflammatory response GO:0002523
The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.
3 P05109 (/IDA) P05109 (/IDA) P05109 (/IDA)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
3 P05109 (/IDA) P05109 (/IDA) P05109 (/IDA)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
3 P05109 (/IDA) P05109 (/IDA) P05109 (/IDA)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Peptidyl-cysteine S-nitrosylation GO:0018119
The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine.
3 P05109 (/IMP) P05109 (/IMP) P05109 (/IMP)
Antimicrobial humoral response GO:0019730
An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
3 P05109 (/IDA) P05109 (/IDA) P05109 (/IDA)
Sequestering of zinc ion GO:0032119
The process of binding or confining zinc ions such that they are separated from other components of a biological system.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Chemokine production GO:0032602
The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
3 P05109 (/IDA) P05109 (/IDA) P05109 (/IDA)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Regulation of cytoskeleton organization GO:0051493
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Neutrophil aggregation GO:0070488
The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules.
3 P05109 (/IDA) P05109 (/IDA) P05109 (/IDA)
Positive regulation of intrinsic apoptotic signaling pathway GO:2001244
Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.
3 P05109 (/IDA) P05109 (/IDA) P05109 (/IDA)
Leukocyte migration involved in inflammatory response GO:0002523
The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.
2 P27005 (/ISO) P27005 (/ISO)
Positive regulation of peptide secretion GO:0002793
Any process that activates or increases the frequency, rate, or extent of peptide secretion.
2 P27005 (/IDA) P27005 (/IDA)
Positive regulation of peptide secretion GO:0002793
Any process that activates or increases the frequency, rate, or extent of peptide secretion.
2 P27005 (/IMP) P27005 (/IMP)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
2 P27005 (/ISO) P27005 (/ISO)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
2 P27005 (/ISO) P27005 (/ISO)
Astrocyte development GO:0014002
The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
2 P27005 (/IGI) P27005 (/IGI)
Peptidyl-cysteine S-nitrosylation GO:0018119
The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine.
2 P27005 (/ISO) P27005 (/ISO)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
2 P27005 (/ISO) P27005 (/ISO)
Autocrine signaling GO:0035425
Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type.
2 P27005 (/ISO) P27005 (/ISO)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
2 P27005 (/ISO) P27005 (/ISO)
Neutrophil aggregation GO:0070488
The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules.
2 P27005 (/ISO) P27005 (/ISO)
Positive regulation of intrinsic apoptotic signaling pathway GO:2001244
Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.
2 P27005 (/ISO) P27005 (/ISO)
Acute inflammatory response GO:0002526
Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
1 P50115 (/IEP)
Chronic inflammatory response GO:0002544
Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.
1 P50115 (/IEP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 P50115 (/NAS)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 P50115 (/IEP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P50115 (/IEP)
Autocrine signaling GO:0035425
Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type.
1 P50115 (/IGI)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 P50115 (/IEP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P50115 (/IEP)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
4 P05109 (/IDA) P05109 (/IDA) P05109 (/IDA) P50115 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P05109 (/HDA) P05109 (/HDA) P05109 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P05109 (/HDA) P05109 (/HDA) P05109 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P05109 (/HDA) P05109 (/HDA) P05109 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P05109 (/IDA) P05109 (/IDA) P05109 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
3 P05109 (/TAS) P05109 (/TAS) P05109 (/TAS)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
3 P05109 (/IDA) P05109 (/IDA) P05109 (/IDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
3 P05109 (/HDA) P05109 (/HDA) P05109 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 P05109 (/HDA) P05109 (/HDA) P05109 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P27005 (/ISO) P27005 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P27005 (/ISO) P27005 (/ISO)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
2 P27005 (/ISO) P27005 (/ISO)