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CATH Superfamily 1.10.238.10

EF-hand

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 270: calpain-3 isoform X7

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Calpain-2. [EC: 3.4.22.53]
Broad endopeptidase specificity.
  • Cytosolic in animal cells.
  • The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52.
  • Belongs to peptidase family C2.
  • Formerly EC 3.4.22.17 and EC 3.4.24.5.
 1 P43367
Calpain-1. [EC: 3.4.22.52]
Broad endopeptidase specificity.
  • Cytosolic in animal cells.
  • The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53.
  • Belongs to peptidase family C2.
  • Formerly EC 3.4.22.17 and EC 3.4.24.5.
 1 P06815