The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 205: calcineurin B homologous protein 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
10 A0AVX7 (/ISS) D3ZTN1 (/ISS) D3ZTN1 (/ISS) D3ZTN1 (/ISS) Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
9 A0AVX7 (/ISS) Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS)
Phosphatase inhibitor activity GO:0019212
Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
9 A0AVX7 (/ISS) Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
9 A0AVX7 (/ISS) Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
8 Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q9JKL5 (/IDA) Q9JKL5 (/IDA) Q9JKL5 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 Q96BS2 (/IPI) Q96BS2 (/IPI) Q96BS2 (/IPI) Q96BS2 (/IPI) Q96BS2 (/IPI)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
3 Q9JKL5 (/IDA) Q9JKL5 (/IDA) Q9JKL5 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Phosphatase inhibitor activity GO:0019212
Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
3 Q9JKL5 (/IDA) Q9JKL5 (/IDA) Q9JKL5 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 Q9JKL5 (/IDA) Q9JKL5 (/IDA) Q9JKL5 (/IDA)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of granulocyte differentiation GO:0030854
Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.
7 A0AVX7 (/ISS) Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS)
Positive regulation of sodium:proton antiporter activity GO:0032417
Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
7 A0AVX7 (/ISS) Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
7 A0AVX7 (/ISS) Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS)
Protein maturation GO:0051604
Any process leading to the attainment of the full functional capacity of a protein.
7 A0AVX7 (/ISS) Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS)
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
7 A0AVX7 (/ISS) Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
7 A0AVX7 (/ISS) Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
6 D3ZTN1 (/ISS) D3ZTN1 (/ISS) D3ZTN1 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
6 D3ZTN1 (/ISS) D3ZTN1 (/ISS) D3ZTN1 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS)
Regulation of cell adhesion mediated by integrin GO:0033628
Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
6 D3ZTN1 (/ISS) D3ZTN1 (/ISS) D3ZTN1 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS)
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
6 D3ZTN1 (/ISS) D3ZTN1 (/ISS) D3ZTN1 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
6 D3ZTN1 (/ISS) D3ZTN1 (/ISS) D3ZTN1 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
5 Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
5 Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP)
Positive regulation of granulocyte differentiation GO:0030854
Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.
5 Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA)
Positive regulation of sodium:proton antiporter activity GO:0032417
Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
5 Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA)
Regulation of cell adhesion mediated by integrin GO:0033628
Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
5 Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP)
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
5 Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
5 Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP) Q96BS2 (/IMP)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
5 Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA)
Protein maturation GO:0051604
Any process leading to the attainment of the full functional capacity of a protein.
5 Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA)
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
5 Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
5 Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA)
Cellular sodium ion homeostasis GO:0006883
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
3 Q9JKL5 (/IEP) Q9JKL5 (/IEP) Q9JKL5 (/IEP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Megakaryocyte differentiation GO:0030219
The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.
3 Q9JKL5 (/IEP) Q9JKL5 (/IEP) Q9JKL5 (/IEP)
Positive regulation of granulocyte differentiation GO:0030854
Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Positive regulation of sodium:proton antiporter activity GO:0032417
Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Regulation of cell adhesion mediated by integrin GO:0033628
Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Protein maturation GO:0051604
Any process leading to the attainment of the full functional capacity of a protein.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
14 D3ZTN1 (/ISS) D3ZTN1 (/ISS) D3ZTN1 (/ISS) Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS)
(4 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 A0AVX7 (/ISS) D3ZTN1 (/ISS) D3ZTN1 (/ISS) D3ZTN1 (/ISS) Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
10 A0AVX7 (/ISS) D3ZTN1 (/ISS) D3ZTN1 (/ISS) D3ZTN1 (/ISS) Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS) Q9JKL5 (/ISS)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
9 A0AVX7 (/ISS) Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS) Q96BS2 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 A0AVX7 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q9JKL5 (/IDA) Q9JKL5 (/IDA) Q9JKL5 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 A0AVX7 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q9JKL5 (/IDA) Q9JKL5 (/IDA) Q9JKL5 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
8 Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q9JKL5 (/IDA) Q9JKL5 (/IDA) Q9JKL5 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA) Q96BS2 (/IDA)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
3 Q9JKL5 (/IDA) Q9JKL5 (/IDA) Q9JKL5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q0V9B1 (/ISS) Q5U554 (/ISS) Q5U554 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
3 Q9JKL5 (/ISO) Q9JKL5 (/ISO) Q9JKL5 (/ISO)