The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Saposin-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: prosaposin isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 P07602 (/IPI) P07602 (/IPI)
Beta-galactosidase activity GO:0004565
Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.
2 P07602 (/IDA) P07602 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P07602 (/IPI) P07602 (/IPI)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
2 P07602 (/IDA) P07602 (/IDA)
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
2 P07602 (/TAS) P07602 (/TAS)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
2 P07602 (/TAS) P07602 (/TAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P07602 (/IDA) P07602 (/IDA)
Ganglioside GM1 binding GO:1905573
Interacting selectively and non-covalently with ganglioside GM1.
2 P07602 (/IDA) P07602 (/IDA)
Ganglioside GM2 binding GO:1905574
Interacting selectively and non-covalently with ganglioside GM2.
2 P07602 (/IDA) P07602 (/IDA)
Ganglioside GM3 binding GO:1905575
Interacting selectively and non-covalently with ganglioside GM3.
2 P07602 (/IDA) P07602 (/IDA)
Ganglioside GT1b binding GO:1905576
Interacting selectively and non-covalently with ganglioside GT1b.
2 P07602 (/IDA) P07602 (/IDA)
Ganglioside GP1c binding GO:1905577
Interacting selectively and non-covalently with ganglioside GP1c.
2 P07602 (/IDA) P07602 (/IDA)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
2 P07602 (/TAS) P07602 (/TAS)
Glycosphingolipid metabolic process GO:0006687
The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide.
2 P07602 (/TAS) P07602 (/TAS)
Lipid transport GO:0006869
The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
2 P07602 (/TAS) P07602 (/TAS)
Lysosomal transport GO:0007041
The directed movement of substances into, out of or within a lysosome.
2 P07602 (/IDA) P07602 (/IDA)
Lysosomal transport GO:0007041
The directed movement of substances into, out of or within a lysosome.
2 P07602 (/IMP) P07602 (/IMP)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P07602 (/TAS) P07602 (/TAS)
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
2 P07602 (/TAS) P07602 (/TAS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 P07602 (/TAS) P07602 (/TAS)
Ganglioside GM1 transport to membrane GO:1905572
The directed movement of ganglioside GM1 to membrane.
2 P07602 (/IDA) P07602 (/IDA)
Lysosomal transport GO:0007041
The directed movement of substances into, out of or within a lysosome.
1 P26779 (/ISS)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
5 A0A024QZQ2 (/IDA) A0A024QZQ2 (/IDA) C9JIZ6 (/IDA) P07602 (/IDA) P07602 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 F1SU97 (/HDA) P07602 (/HDA) P07602 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P07602 (/HDA) P07602 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P07602 (/TAS) P07602 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P07602 (/IDA) P07602 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P07602 (/ISS) P07602 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P07602 (/TAS) P07602 (/TAS)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
2 P07602 (/IDA) P07602 (/IDA)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
2 P07602 (/TAS) P07602 (/TAS)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
2 P07602 (/IDA) P07602 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P07602 (/TAS) P07602 (/TAS)
Azurophil granule membrane GO:0035577
The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
2 P07602 (/TAS) P07602 (/TAS)
Lysosomal lumen GO:0043202
The volume enclosed within the lysosomal membrane.
2 P07602 (/TAS) P07602 (/TAS)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
2 P07602 (/HDA) P07602 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P07602 (/HDA) P07602 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P26779 (/ISS)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 P26779 (/ISS)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 P26779 (/ISS)