The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Saposin-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: prosaposin isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 23 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P07602 (/IPI) P07602 (/IPI) Q61207 (/IPI) Q61207 (/IPI)
G protein-coupled receptor binding GO:0001664
Interacting selectively and non-covalently with a G protein-coupled receptor.
2 Q61207 (/IPI) Q61207 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 P07602 (/IPI) P07602 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 Q61207 (/ISO) Q61207 (/ISO)
Beta-galactosidase activity GO:0004565
Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.
2 P07602 (/IDA) P07602 (/IDA)
Beta-galactosidase activity GO:0004565
Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.
2 Q61207 (/ISO) Q61207 (/ISO)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
2 P07602 (/IDA) P07602 (/IDA)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
2 Q61207 (/ISO) Q61207 (/ISO)
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
2 P07602 (/TAS) P07602 (/TAS)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
2 P07602 (/TAS) P07602 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q61207 (/ISO) Q61207 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P07602 (/IDA) P07602 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q61207 (/ISO) Q61207 (/ISO)
Ganglioside GM1 binding GO:1905573
Interacting selectively and non-covalently with ganglioside GM1.
2 P07602 (/IDA) P07602 (/IDA)
Ganglioside GM1 binding GO:1905573
Interacting selectively and non-covalently with ganglioside GM1.
2 Q61207 (/ISO) Q61207 (/ISO)
Ganglioside GM2 binding GO:1905574
Interacting selectively and non-covalently with ganglioside GM2.
2 P07602 (/IDA) P07602 (/IDA)
Ganglioside GM2 binding GO:1905574
Interacting selectively and non-covalently with ganglioside GM2.
2 Q61207 (/ISO) Q61207 (/ISO)
Ganglioside GM3 binding GO:1905575
Interacting selectively and non-covalently with ganglioside GM3.
2 P07602 (/IDA) P07602 (/IDA)
Ganglioside GM3 binding GO:1905575
Interacting selectively and non-covalently with ganglioside GM3.
2 Q61207 (/ISO) Q61207 (/ISO)
Ganglioside GT1b binding GO:1905576
Interacting selectively and non-covalently with ganglioside GT1b.
2 P07602 (/IDA) P07602 (/IDA)
Ganglioside GT1b binding GO:1905576
Interacting selectively and non-covalently with ganglioside GT1b.
2 Q61207 (/ISO) Q61207 (/ISO)
Ganglioside GP1c binding GO:1905577
Interacting selectively and non-covalently with ganglioside GP1c.
2 P07602 (/IDA) P07602 (/IDA)
Ganglioside GP1c binding GO:1905577
Interacting selectively and non-covalently with ganglioside GP1c.
2 Q61207 (/ISO) Q61207 (/ISO)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lysosomal transport GO:0007041
The directed movement of substances into, out of or within a lysosome.
4 P10960 (/ISS) P26779 (/ISS) Q61207 (/ISS) Q61207 (/ISS)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
2 P07602 (/TAS) P07602 (/TAS)
Corneocyte development GO:0003335
The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis.
2 Q61207 (/IMP) Q61207 (/IMP)
Sphingolipid metabolic process GO:0006665
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
2 Q61207 (/IMP) Q61207 (/IMP)
Galactosylceramide catabolic process GO:0006683
The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group.
2 Q61207 (/IMP) Q61207 (/IMP)
Glycosphingolipid metabolic process GO:0006687
The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide.
2 P07602 (/TAS) P07602 (/TAS)
Lipid transport GO:0006869
The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
2 P07602 (/TAS) P07602 (/TAS)
Lysosomal transport GO:0007041
The directed movement of substances into, out of or within a lysosome.
2 P07602 (/IDA) P07602 (/IDA)
Lysosomal transport GO:0007041
The directed movement of substances into, out of or within a lysosome.
2 P07602 (/IMP) P07602 (/IMP)
Lysosomal transport GO:0007041
The directed movement of substances into, out of or within a lysosome.
2 Q61207 (/ISO) Q61207 (/ISO)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P07602 (/TAS) P07602 (/TAS)
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
2 Q61207 (/IDA) Q61207 (/IDA)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
2 Q61207 (/IMP) Q61207 (/IMP)
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
2 P07602 (/TAS) P07602 (/TAS)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
2 Q61207 (/IMP) Q61207 (/IMP)
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
2 Q61207 (/IMP) Q61207 (/IMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 P07602 (/TAS) P07602 (/TAS)
Regulation of MAPK cascade GO:0043408
Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.
2 Q61207 (/IMP) Q61207 (/IMP)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
2 Q61207 (/IDA) Q61207 (/IDA)
Developmental growth GO:0048589
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
2 Q61207 (/IMP) Q61207 (/IMP)
Neuromuscular process controlling balance GO:0050885
Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
2 Q61207 (/IMP) Q61207 (/IMP)
Positive regulation of hydrolase activity GO:0051345
Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.
2 Q61207 (/IMP) Q61207 (/IMP)
Micturition GO:0060073
The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body.
2 Q61207 (/IMP) Q61207 (/IMP)
Prostate gland growth GO:0060736
The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state.
2 Q61207 (/IMP) Q61207 (/IMP)
Epithelial cell differentiation involved in prostate gland development GO:0060742
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland.
2 Q61207 (/IMP) Q61207 (/IMP)
Cellular response to organic substance GO:0071310
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
2 Q61207 (/IMP) Q61207 (/IMP)
Cochlea development GO:0090102
The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.
2 Q61207 (/IMP) Q61207 (/IMP)
Walking behavior GO:0090659
The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
2 Q61207 (/IMP) Q61207 (/IMP)
Negative regulation of hydrogen peroxide-induced cell death GO:1903206
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.
2 Q61207 (/IDA) Q61207 (/IDA)
Cornified envelope assembly GO:1903575
The aggregation, arrangement and bonding together of a set of components to form a cornified envelope.
2 Q61207 (/IMP) Q61207 (/IMP)
Ganglioside GM1 transport to membrane GO:1905572
The directed movement of ganglioside GM1 to membrane.
2 P07602 (/IDA) P07602 (/IDA)
Ganglioside GM1 transport to membrane GO:1905572
The directed movement of ganglioside GM1 to membrane.
2 Q61207 (/ISO) Q61207 (/ISO)
Glycolipid transport GO:0046836
The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P10960 (/NAS)

There are 25 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
5 F1SU97 (/HDA) P07602 (/HDA) P07602 (/HDA) Q61207 (/HDA) Q61207 (/HDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
5 A0A024QZQ2 (/IDA) A0A024QZQ2 (/IDA) C9JIZ6 (/IDA) P07602 (/IDA) P07602 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
4 P10960 (/ISS) P26779 (/ISS) Q61207 (/ISS) Q61207 (/ISS)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
4 P10960 (/ISS) P26779 (/ISS) Q61207 (/ISS) Q61207 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P07602 (/HDA) P07602 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 Q61207 (/IDA) Q61207 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P10960 (/ISS) P26779 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P07602 (/TAS) P07602 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P07602 (/IDA) P07602 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q61207 (/ISO) Q61207 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P07602 (/ISS) P07602 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P07602 (/TAS) P07602 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q61207 (/IDA) Q61207 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q61207 (/HDA) Q61207 (/HDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
2 P07602 (/IDA) P07602 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
2 Q61207 (/ISO) Q61207 (/ISO)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
2 P07602 (/TAS) P07602 (/TAS)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
2 P07602 (/IDA) P07602 (/IDA)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
2 Q61207 (/ISO) Q61207 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P07602 (/TAS) P07602 (/TAS)
Azurophil granule membrane GO:0035577
The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
2 P07602 (/TAS) P07602 (/TAS)
Lysosomal lumen GO:0043202
The volume enclosed within the lysosomal membrane.
2 P07602 (/TAS) P07602 (/TAS)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 Q61207 (/ISO) Q61207 (/ISO)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
2 P07602 (/HDA) P07602 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P07602 (/HDA) P07602 (/HDA)