The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Saposin-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Mesencephalic astrocyte-derived neurotrophic facto...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sulfatide binding GO:0120146
Interacting selectively and non-covalently with sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group.
3 P55145 (/IPI) P55145 (/IPI) Q9N3B0 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 P55145 (/HDA) P55145 (/HDA)
Sulfatide binding GO:0120146
Interacting selectively and non-covalently with sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group.
1 Q9CXI5 (/ISO)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
3 A0A0B5JF91 (/IMP) F1QDQ5 (/IMP) Q08CA7 (/IMP)
Regulation of response to endoplasmic reticulum stress GO:1905897
Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress.
3 P55145 (/IMP) P55145 (/IMP) Q9N3B0 (/IMP)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
2 P55145 (/TAS) P55145 (/TAS)
Synaptic transmission, dopaminergic GO:0001963
The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 Q9XZ63 (/IMP)
Vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure GO:0002014
The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system.
1 Q9CXI5 (/IDA)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q9XZ63 (/IMP)
Dopamine metabolic process GO:0042417
The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
1 Q9XZ63 (/IMP)
Developmental growth GO:0048589
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
1 Q9N3B0 (/IMP)
Neuron cellular homeostasis GO:0070050
The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.
1 Q9XZ63 (/IMP)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 Q9N3B0 (/IMP)
Regulation of response to endoplasmic reticulum stress GO:1905897
Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress.
1 Q9CXI5 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
4 P0C5H9 (/IDA) P0C5H9 (/IDA) P0C5H9 (/IDA) P0C5H9 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
4 P0C5H9 (/IDA) P0C5H9 (/IDA) P0C5H9 (/IDA) P0C5H9 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P55145 (/TAS) P55145 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P55145 (/HDA) P55145 (/HDA)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
2 P55145 (/IDA) P55145 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P55145 (/TAS) P55145 (/TAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q9XZ63 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q9XZ63 (/IDA)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
1 Q9CXI5 (/ISO)
Endomembrane system GO:0012505
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
1 Q9XZ63 (/HDA)