The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: DnaA protein, C-terminal DNA-binding domain

The DnaA protein binds to a region of the chromosome known as the origin of replication (oriC). In Escherichia coli, oriC contains several nonamer DnaA binding sites (DnaA boxes), some of which bind DnaA strongly and are occupied throughout the cell cycle. DnaA is conserved in bacteria, in agreement with the importance of its function. Based on its modular organization, the DnaA protein can be divided into four domains: the N-terminal domain, a linker of an unknown function, the central highly conserved AAA+-motif-containing ATPase domain and the C-terminal DnaA-box DNA binding domain (DBD).

This entry represents the DNA binding domain (DBD) which is entirely alpha-helical and binds its cognate DNA through sequence-specific interactions with bases spanning 9 bp and through non-specific interactions with the phosphodiester backbone. The DnaA DBD resembles several transcription factors in its protein fold and interaction with DNA, for example, the Trp repressor TrpR.


GO Diversity

Unique GO annotations
15 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
13074 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 14
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 2
Unique PDBs: 6
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 17
Unique EC:
Unique GO: 15
Unique Species: 13074