The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease III domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 3: Drosha ribonuclease III

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q5HZJ0 (/IPI) Q9NRR4 (/IPI) Q9NRR4 (/IPI)
Lipopolysaccharide binding GO:0001530
Interacting selectively and non-covalently with lipopolysaccharide.
2 Q9NRR4 (/IDA) Q9NRR4 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q9NRR4 (/HDA) Q9NRR4 (/HDA)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
2 Q7KNF1 (/ISS) Q960Y4 (/ISS)
Ribonuclease III activity GO:0004525
Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
2 Q9NRR4 (/IDA) Q9NRR4 (/IDA)
DEAD/H-box RNA helicase binding GO:0017151
Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase.
2 Q9NRR4 (/IPI) Q9NRR4 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q9NRR4 (/IDA) Q9NRR4 (/IDA)
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
2 Q9NRR4 (/IPI) Q9NRR4 (/IPI)
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
2 Q9NRR4 (/IPI) Q9NRR4 (/IPI)
Primary miRNA binding GO:0070878
Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding.
2 Q9NRR4 (/IPI) Q9NRR4 (/IPI)
Primary miRNA binding GO:0070878
Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding.
2 Q9NRR4 (/NAS) Q9NRR4 (/NAS)
Lipopolysaccharide binding GO:0001530
Interacting selectively and non-covalently with lipopolysaccharide.
1 Q5HZJ0 (/ISO)
Endoribonuclease activity GO:0004521
Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
1 Q5HZJ0 (/IDA)
Ribonuclease III activity GO:0004525
Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
1 Q5HZJ0 (/ISO)
DEAD/H-box RNA helicase binding GO:0017151
Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase.
1 Q5HZJ0 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q5HZJ0 (/ISO)
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
1 Q5HZJ0 (/ISO)
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
1 Q5HZJ0 (/ISO)
Primary miRNA binding GO:0070878
Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding.
1 Q5HZJ0 (/ISO)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Primary miRNA processing GO:0031053
Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule.
4 Q7KNF1 (/IMP) Q960Y4 (/IMP) Q9NRR4 (/IMP) Q9NRR4 (/IMP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 A2RV16 (/IMP) F1QKS5 (/IMP)
Germarium-derived oocyte fate determination GO:0007294
The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster.
2 Q7KNF1 (/IMP) Q960Y4 (/IMP)
MiRNA metabolic process GO:0010586
The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
2 Q9NRR4 (/TAS) Q9NRR4 (/TAS)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
2 Q7KNF1 (/IMP) Q960Y4 (/IMP)
Germarium-derived female germ-line cyst formation GO:0030727
Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster.
2 Q7KNF1 (/IMP) Q960Y4 (/IMP)
Primary miRNA processing GO:0031053
Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule.
2 Q9NRR4 (/IDA) Q9NRR4 (/IDA)
Salivary gland histolysis GO:0035070
The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly.
2 Q7KNF1 (/IMP) Q960Y4 (/IMP)
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
2 A2RV16 (/IMP) F1QKS5 (/IMP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
2 Q9NRR4 (/IDA) Q9NRR4 (/IDA)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
2 Q9NRR4 (/IDA) Q9NRR4 (/IDA)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q5HZJ0 (/IMP)
MiRNA metabolic process GO:0010586
The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
1 Q5HZJ0 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q5HZJ0 (/IMP)
Primary miRNA processing GO:0031053
Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule.
1 Q5HZJ0 (/ISO)
Pre-miRNA processing GO:0031054
Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule.
1 Q5HZJ0 (/IDA)
Regulation of regulatory T cell differentiation GO:0045589
Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.
1 Q5HZJ0 (/IMP)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
1 Q5HZJ0 (/IMP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 Q5HZJ0 (/ISO)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 Q5HZJ0 (/ISO)
Regulation of miRNA metabolic process GO:2000628
Any process that modulates the frequency, rate or extent of miRNA metabolic process.
1 Q5HZJ0 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microprocessor complex GO:0070877
A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs.
3 Q7KNF1 (/IDA) Q9NRR4 (/IDA) Q9NRR4 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q9NRR4 (/TAS) Q9NRR4 (/TAS)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 Q5HZJ0 (/IDA)
Microprocessor complex GO:0070877
A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs.
1 Q5HZJ0 (/ISO)