View in Gene3D

CATH Superfamily 1.10.150.80

HRDC domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
HRDC domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA helicase. [EC: 3.6.4.12]
ATP + H(2)O = ADP + phosphate.
  • DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA.
  • Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15).
  • Some helicases unwind DNA as well as RNA (4,9).
  • May be identical with EC 3.6.4.13 (RNA helicase).
 76 A0A025C609 A0A027ZJX4 A0A028E3C9 A0A069XH98 A0A070SMX6 A0A070UFZ5 A0A080ICH2 A0A0A0F7G5 A0A0E0U5P6 A0A0E0Y5U1
(66 more...)
Ribonuclease D. [EC: 3.1.13.5]
Exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides.
  • Alteration of the 3'-terminal base has no effect on the rate of hydrolysis whereas modification of the 3'-terminal sugar has a major effect.
  • tRNA terminating with a 3'-phosphate is completely inactive.
  • This enzyme can convert a tRNA precursor into a mature tRNA.
 47 A0A066PPT1 A0A0H3FXF3 A0A1R1K5T7 A0A1R1K5T7 A0A1S9J836 A0A1S9J836 A0A236Q1L0 A0A236Q1L0 A0A2R4RXK7 A0A2R4S3Y1
(37 more...)