CATH Superfamily 188.8.131.52
Tyrosine recombinase, N-terminal domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
This superfamily consists of structural domains found at the N-terminus of phage integrases and Cre recombinases, which are classified as tyrosine recombinanses (formerly referred to as the lambda-integrase family) PMID:15591069. Members of this superfamily include: the bacteriophage lambda integrase PMID:18540053, Cre recombinases PMID:17573343 from P1 phage, XerD from E. coli PMID:9311978, Flp from yeast, kinetochore protein Ndc10 PMID:22215672. These enzymes are homologous to tyrosine integrase utilise a catalytic tyrosine to mediate strand cleavage, tend to recognise longer attP sequences, and require other proteins encoded by the phage or the host bacteria.
The 356 amino acid lambda integrase consists of two domains: an N-terminal domain (NTD) that includes residues 1 - 64 and is responsible for binding the arm-type sites of attP, and a C-terminal domain that binds the lower affinity core-type sites and contains the catalytic site. The NTD adopts a 4-5 helical bundle fold with two orthogonally packed alpha-hairpins.
INTERPRO:IPR010998, INTERPRO:IPR002104, PFAM:PF02899, [PfamClan:CL0469]
|Domain clusters (>95% seq id):||20|
|Domain clusters (>35% seq id):||19|
|Structural Clusters (5A):||3|
|Structural Clusters (9A):||1|