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CATH Superfamily 1.10.150.120

[2Fe-2S]-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
[2Fe-2S]-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Carbon monoxide dehydrogenase, small subunit

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glyceraldehyde dehydrogenase (FAD-containing). [EC: 1.2.99.8]
D-glyceraldehyde + H(2)O + acceptor = D-glycerate + reduced acceptor.
  • The enzyme from the archaeon Sulfolobus acidocaldarius catalyzes the oxidation of D-glyceraldehyde in the nonphosphorylative Entner- Doudoroff pathway.
  • With 2,6-dichlorophenolindophenol as artificial electron acceptor, the enzyme shows a broad substrate range, but is most active with D-glyceraldehyde.
  • It is not known which acceptor is utilized in vivo.
 16 A0A0U2W5Q9 A0A0U2W5Q9 A0A0U2W5Q9 A0A0U2W5Q9 M1IY76 M1IY76 M1IY76 M1IY76 M1J5D1 M1J5D1
(6 more...)
Nicotinate dehydrogenase (cytochrome). [EC: 1.17.2.1]
Nicotinate + a ferricytochrome + H(2)O = 6-hydroxynicotinate + a ferrocytochrome + 2 H(+).
  • This two-component enzyme from Pseudomonas belongs to the family of xanthine dehydrogenases, but differs from most other members of this family.
  • While most members contain an FAD cofactor, the large subunit of this enzyme contains three c-type cytochromes, enabling it to interact with the electron transfer chain, probably by delivering the electrons to a cytochrome oxidase.
 4 A0A2V4FBT3 A0A2V4FBT3 Q88FX9 Q88FX9
Caffeine dehydrogenase. [EC: 1.17.5.2]
Caffeine + ubiquinone + H(2)O = 1,3,7-trimethylurate + ubiquinol.
  • This enzyme, characterized from the soil bacterium Pseudomonas sp. CBB1, catalyzes the incorporation of an oxygen atom originating from a water molecule into position C-8 of caffeine.
  • The enzyme utilizes short-tail ubiquinones as the preferred electron acceptor.
 1 D7REY5
Nicotinate dehydrogenase. [EC: 1.17.1.5]
Nicotinate + H(2)O + NADP(+) = 6-hydroxynicotinate + NADPH.
  • The enzyme is capable of acting on a variety of nicotinate analogs to varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3- dicarboxylate, trigonelline and 6-methylnicotinate.
  • The enzyme from Clostridium barkeri also possesses a catalytically essential, labile selenium that can be removed by reaction with cyanide.
  • Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri.
  • Other enzymes involved in this pathway are EC 1.3.7.1, EC 3.5.2.18, EC 1.1.1.291, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32.
  • Formerly EC 1.5.1.13.
 1 Q0QLF3