The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"[2Fe-2S]-binding domain
".
FunFam 16:
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Xanthine dehydrogenase activity GO:0004854
Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
|
2 | Q12553 (/IDA) R4ZGN4 (/IDA) |
|
Molybdopterin cofactor binding GO:0043546
Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.
|
2 | Q12553 (/ISS) R4ZGN4 (/ISS) |
|
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
|
2 | Q12553 (/ISS) R4ZGN4 (/ISS) |
|
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
|
2 | Q12553 (/ISS) R4ZGN4 (/ISS) |
|
Xanthine dehydrogenase activity GO:0004854
Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
|
1 | Q12553 (/IMP) |
|
Xanthine dehydrogenase activity GO:0004854
Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
|
1 | Q12553 (/ISS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | R4ZGN4 (/IDA) |
There are 12 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Purine nucleobase catabolic process GO:0006145
The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
|
2 | Q12553 (/IDA) R4ZGN4 (/IDA) |
|
Purine nucleobase catabolic process GO:0006145
The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
|
1 | Q12553 (/IMP) |
|
Guanine catabolic process GO:0006147
The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.
|
1 | R4ZGN4 (/IDA) |
|
Hypoxanthine oxidation GO:0006150
The chemical reactions and pathways resulting in the breakdown of hypoxanthine to xanthine and thence to uric acid.
|
1 | R4ZGN4 (/IDA) |
|
Xanthine oxidation GO:0006151
The oxidation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.
|
1 | R4ZGN4 (/IDA) |
|
Xanthine catabolic process GO:0009115
The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.
|
1 | Q12553 (/ISS) |
|
Cellular response to ammonium ion GO:0071242
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus.
|
1 | R4ZGN4 (/IEP) |
|
Cellular response to nitrate GO:0071249
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus.
|
1 | R4ZGN4 (/IEP) |
|
Cellular response to cadmium ion GO:0071276
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
|
1 | R4ZGN4 (/IDA) |
|
Cellular response to copper ion GO:0071280
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
|
1 | R4ZGN4 (/IDA) |
|
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
|
1 | R4ZGN4 (/IDA) |
|
Cellular response to zinc ion GO:0071294
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
|
1 | R4ZGN4 (/IDA) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | R4ZGN4 (/IDA) |