The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"[2Fe-2S]-binding domain
".
FunFam 12: Xanthine dehydrogenase 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Xanthine dehydrogenase activity GO:0004854
Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
|
1 | Q8GUQ8 (/IDA) |
|
Xanthine dehydrogenase activity GO:0004854
Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
|
1 | Q54FB7 (/ISS) |
|
Molybdopterin cofactor binding GO:0043546
Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.
|
1 | Q54FB7 (/ISS) |
|
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
|
1 | Q54FB7 (/ISS) |
|
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
|
1 | Q54FB7 (/ISS) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Xanthine metabolic process GO:0046110
The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.
|
2 | F4JLI5 (/IMP) Q8GUQ8 (/IMP) |
|
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
|
1 | Q8GUQ8 (/IMP) |
|
Purine nucleobase catabolic process GO:0006145
The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
|
1 | Q8GUQ8 (/IMP) |
|
Purine nucleobase catabolic process GO:0006145
The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
|
1 | Q8GUQ8 (/TAS) |
|
Xanthine catabolic process GO:0009115
The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.
|
1 | Q54FB7 (/ISS) |
|
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
|
1 | Q8GUQ8 (/IMP) |
|
Superoxide anion generation GO:0042554
The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.
|
1 | Q8GUQ8 (/IMP) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8GUQ8 (/IDA) |