The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Putative poly(A) polymerase gamma

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Polynucleotide adenylyltransferase activity GO:0004652
Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
28 A0A0B4KG96 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS)
(18 more)
Polynucleotide adenylyltransferase activity GO:0004652
Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
21 A0A0B4KG96 (/IDA) P25500 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P51003 (/IDA) P51003 (/IDA)
(11 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
21 O82312 (/IPI) O82312 (/IPI) P29468 (/IPI) P29468 (/IPI) P29468 (/IPI) P29468 (/IPI) P29468 (/IPI) P29468 (/IPI) P51003 (/IPI) P51003 (/IPI)
(11 more)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
7 P25500 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
7 P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) Q61183 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
7 P25500 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
7 P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) Q61183 (/ISS)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
7 P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) Q61183 (/ISS)
Polynucleotide adenylyltransferase activity GO:0004652
Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
6 P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
3 Q9BWT3 (/IDA) Q9BWT3 (/IDA) Q9BWT3 (/IDA)
Polynucleotide adenylyltransferase activity GO:0004652
Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
2 Q61183 (/ISO) Q6PCL9 (/ISO)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q9UW26 (/IDA)
Polynucleotide adenylyltransferase activity GO:0004652
Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
1 Q10295 (/IGI)
Polynucleotide adenylyltransferase activity GO:0004652
Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
1 Q9WVP6 (/ISA)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
1 P25500 (/IDA)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
1 Q6PCL9 (/ISO)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
1 Q6PCL9 (/ISS)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA polyadenylation GO:0006378
The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
19 A0A0B4KG96 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS) C6KT92 (/ISS)
(9 more)
RNA polyadenylation GO:0043631
The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule.
16 O82312 (/IDA) O82312 (/IDA) P25500 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) Q61183 (/IDA)
(6 more)
MRNA polyadenylation GO:0006378
The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
13 P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P51003 (/IDA) P51003 (/IDA) P51003 (/IDA) P51003 (/IDA)
(3 more)
RNA polyadenylation GO:0043631
The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule.
8 P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) P51003 (/ISS) Q61183 (/ISS) Q6PCL9 (/ISS)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
6 P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS)
Termination of RNA polymerase II transcription GO:0006369
The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed.
6 P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS)
MRNA polyadenylation GO:0006378
The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
6 P29468 (/IMP) P29468 (/IMP) P29468 (/IMP) P29468 (/IMP) P29468 (/IMP) P29468 (/IMP)
MRNA 3'-end processing GO:0031124
Any process involved in forming the mature 3' end of an mRNA molecule.
6 P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS)
Regulation of mRNA 3'-end processing GO:0031440
Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule.
6 P51003 (/IDA) P51003 (/IDA) P51003 (/IDA) P51003 (/IDA) P51003 (/IDA) P51003 (/IDA)
SnoRNA polyadenylation GO:0071050
The enzymatic addition of a sequence of adenylyl residues at the 3' end of snoRNA molecule. In eukaryotes, this occurs in conjunction with termination of transcription of precursor snoRNA molecules and may occur post-transcriptionally on incorrectly processed molecules targeted for degradation.
6 P29468 (/IGI) P29468 (/IGI) P29468 (/IGI) P29468 (/IGI) P29468 (/IGI) P29468 (/IGI)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 Q9LMT2 (/IMP) Q9LMT2 (/IMP)
Flower development GO:0009908
The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem.
2 Q9LMT2 (/IMP) Q9LMT2 (/IMP)
Regulation of mRNA 3'-end processing GO:0031440
Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule.
2 P25500 (/ISS) Q61183 (/ISS)
Single-species biofilm formation on inanimate substrate GO:0044011
A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.
2 O42617 (/IMP) Q9UW26 (/IMP)
Negative regulation of innate immune response GO:0045824
Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
2 Q9LMT2 (/IMP) Q9LMT2 (/IMP)
Leaf development GO:0048366
The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure.
2 Q9LMT2 (/IMP) Q9LMT2 (/IMP)
Petal formation GO:0048451
The process that gives rise to the petal. This process pertains to the initial formation of a structure from unspecified parts.
2 Q9LMT2 (/IMP) Q9LMT2 (/IMP)
MRNA polyadenylation GO:0006378
The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
1 Q10295 (/IGI)
MRNA polyadenylation GO:0006378
The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
1 Q61183 (/ISO)
Regulation of mRNA 3'-end processing GO:0031440
Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule.
1 Q61183 (/ISO)
Nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts GO:0033621
The chemical reactions and pathways resulting in the selective degradation of meiosis-specific transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein.
1 Q10295 (/IMP)
RNA polyadenylation GO:0043631
The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule.
1 Q9WVP6 (/ISA)
RNA polyadenylation GO:0043631
The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule.
1 Q6PCL9 (/ISO)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
21 A0A024R6M3 (/IDA) A0A024R6M3 (/IDA) A0A024R6M3 (/IDA) A0A024R6M3 (/IDA) A0A024R6M3 (/IDA) A0A024R6M3 (/IDA) G3XAH6 (/IDA) G3XAH6 (/IDA) G3XAH6 (/IDA) G3XAH6 (/IDA)
(11 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 O82312 (/IDA) O82312 (/IDA) Q10295 (/IDA) Q8VYW1 (/IDA) Q9BWT3 (/IDA) Q9BWT3 (/IDA) Q9BWT3 (/IDA) Q9LMT2 (/IDA) Q9LMT2 (/IDA) Q9WVP6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 P29468 (/IPI) P29468 (/IPI) P29468 (/IPI) P29468 (/IPI) P29468 (/IPI) P29468 (/IPI)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS) P51003 (/TAS)
MRNA cleavage and polyadenylation specificity factor complex GO:0005847
A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.
6 P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA) P29468 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q10295 (/IDA) Q9BWT3 (/IDA) Q9BWT3 (/IDA) Q9BWT3 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q9BWT3 (/HDA) Q9BWT3 (/HDA) Q9BWT3 (/HDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
3 Q9BWT3 (/IDA) Q9BWT3 (/IDA) Q9BWT3 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q61183 (/ISO) Q6PCL9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q56XM9 (/IDA) Q9WVP6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q10295 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6PCL9 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6PCL9 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q9WVP6 (/IPI)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q6PCL9 (/ISO)
MRNA cleavage and polyadenylation specificity factor complex GO:0005847
A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.
1 Q10295 (/IGI)
MRNA cleavage and polyadenylation specificity factor complex GO:0005847
A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.
1 Q54J73 (/ISS)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q6PCL9 (/ISO)
Mmi1 nuclear focus GO:1990251
A protein complex that forms during vegetative growth and is involved in the selective degradation of meiosis-specific transcripts. Contains at least Mmi1, or an ortholog of it.
1 Q10295 (/IDA)