The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Neutral endopeptidase , domain2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Membrane metalloendopeptidase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Neprilysin. [EC: 3.4.24.11]
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.
  • A membrane-bound glycoprotein widely distributed in animal tissues.
  • Inhibited by phosphoramidon and thiorphan.
  • Belongs to peptidase family M13.
11 A0A2J8WT66 A0A2J8WT66 P07861 P08049 P08473 P0C1T0 Q495T6 Q5RE69 Q5RE69 Q61391
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