The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Angiotensin-converting enzyme

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Virus receptor activity GO:0001618
Combining with a virus component and mediating entry of the virus into the cell.
9 Q56H28 (/ISS) Q56NL1 (/ISS) Q56NL1 (/ISS) Q58DD0 (/ISS) Q5EGZ1 (/ISS) Q5EGZ1 (/ISS) Q5RFN1 (/ISS) Q8R0I0 (/ISS) Q8R0I0 (/ISS)
Carboxypeptidase activity GO:0004180
Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide.
3 Q5EGZ1 (/IDA) Q5EGZ1 (/IDA) Q9BYF1 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q8R0I0 (/IPI) Q8R0I0 (/IPI) Q9BYF1 (/IPI)
Virus receptor activity GO:0001618
Combining with a virus component and mediating entry of the virus into the cell.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Carboxypeptidase activity GO:0004180
Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Carboxypeptidase activity GO:0004180
Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide.
2 Q8R0I0 (/TAS) Q8R0I0 (/TAS)
Metallocarboxypeptidase activity GO:0004181
Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Virus receptor activity GO:0001618
Combining with a virus component and mediating entry of the virus into the cell.
1 Q9BYF1 (/IDA)
Virus receptor activity GO:0001618
Combining with a virus component and mediating entry of the virus into the cell.
1 Q9BYF1 (/IMP)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
1 Q9BYF1 (/IDA)
Metallocarboxypeptidase activity GO:0004181
Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 Q9BYF1 (/EXP)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q9BYF1 (/TAS)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 A2VD79 (/ISS)
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
1 A2VD79 (/ISS)

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Angiotensin-mediated drinking behavior GO:0003051
The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081
The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Tryptophan transport GO:0015827
The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q8R0I0 (/IMP) Q8R0I0 (/IMP)
Receptor biosynthetic process GO:0032800
The chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Receptor-mediated virion attachment to host cell GO:0046813
The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
2 Q5EGZ1 (/IMP) Q5EGZ1 (/IMP)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Positive regulation of amino acid transport GO:0051957
Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Maternal process involved in female pregnancy GO:0060135
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
2 Q5EGZ1 (/IEP) Q5EGZ1 (/IEP)
Positive regulation of cardiac muscle contraction GO:0060452
Any process that increases the frequency, rate or extent of cardiac muscle contraction.
2 Q8R0I0 (/IMP) Q8R0I0 (/IMP)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q5EGZ1 (/IMP) Q5EGZ1 (/IMP)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Positive regulation of gap junction assembly GO:1903598
Any process that activates or increases the frequency, rate or extent of gap junction assembly.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Regulation of cytokine production GO:0001817
Any process that modulates the frequency, rate, or extent of production of a cytokine.
1 Q9BYF1 (/IC)
Angiotensin maturation GO:0002003
The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood.
1 Q9BYF1 (/IC)
Angiotensin maturation GO:0002003
The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood.
1 Q9BYF1 (/TAS)
Angiotensin-mediated drinking behavior GO:0003051
The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst.
1 Q9BYF1 (/IMP)
Regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081
The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.
1 Q9BYF1 (/IC)
Regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081
The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.
1 Q9BYF1 (/IMP)
Modulation by virus of host morphology or physiology GO:0019048
The process in which a virus effects a change in the structure or processes of its host organism.
1 A2VD79 (/ISS)
Regulation of vasoconstriction GO:0019229
Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels.
1 Q9BYF1 (/IC)
Endoplasmic reticulum unfolded protein response GO:0030968
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
1 A2VD79 (/ISS)
Receptor biosynthetic process GO:0032800
The chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q9BYF1 (/IMP)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
1 Q9BYF1 (/TAS)
Positive regulation of viral genome replication GO:0045070
Any process that activates or increases the frequency, rate or extent of viral genome replication.
1 A2VD79 (/ISS)
Viral entry into host cell GO:0046718
The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
1 Q9BYF1 (/TAS)
Receptor-mediated virion attachment to host cell GO:0046813
The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface.
1 Q9BYF1 (/IDA)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
1 Q9BYF1 (/IC)
Positive regulation of amino acid transport GO:0051957
Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9BYF1 (/IMP)
Regulation of blood vessel diameter GO:0097746
Any process that modulates the diameter of blood vessels.
1 Q9BYF1 (/IC)
Positive regulation of gap junction assembly GO:1903598
Any process that activates or increases the frequency, rate or extent of gap junction assembly.
1 Q9BYF1 (/IMP)
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
1 Q9BYF1 (/IMP)
Positive regulation of reactive oxygen species metabolic process GO:2000379
Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.
1 Q9BYF1 (/IC)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 Q56H28 (/ISS) Q56NL1 (/ISS) Q56NL1 (/ISS) Q58DD0 (/ISS) Q5EGZ1 (/ISS) Q5EGZ1 (/ISS) Q5RFN1 (/ISS) Q8R0I0 (/ISS) Q8R0I0 (/ISS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
9 Q56H28 (/ISS) Q56NL1 (/ISS) Q56NL1 (/ISS) Q58DD0 (/ISS) Q5EGZ1 (/ISS) Q5EGZ1 (/ISS) Q5RFN1 (/ISS) Q8R0I0 (/ISS) Q8R0I0 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 Q5EGZ1 (/IDA) Q5EGZ1 (/IDA) Q9BYF1 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q8R0I0 (/IDA) Q8R0I0 (/IDA) Q9BYF1 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8R0I0 (/IDA) Q8R0I0 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q5EGZ1 (/IDA) Q5EGZ1 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q8R0I0 (/ISO) Q8R0I0 (/ISO)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
2 Q8R0I0 (/IDA) Q8R0I0 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q9BYF1 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 A2VD79 (/ISS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 A2VD79 (/ISS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 A2VD79 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9BYF1 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q9BYF1 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 Q9BYF1 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9BYF1 (/HDA)