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CATH Superfamily 1.10.132.10

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Topoisomerase I

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA topoisomerase type I activity GO:0003917
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
 15 Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS)
(5 more)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
 15 Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS) Q8I3Z9 (/ISS)
(5 more)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
 15 Q8I3Z9 (/IDA) Q8I3Z9 (/IDA) Q8I3Z9 (/IDA) Q8I3Z9 (/IDA) Q8I3Z9 (/IDA) Q8I3Z9 (/IDA) Q8I3Z9 (/IDA) Q8I3Z9 (/IDA) Q8I3Z9 (/IDA) Q8I3Z9 (/IDA)
(5 more)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 15 Q8I3Z9 (/RCA) Q8I3Z9 (/RCA) Q8I3Z9 (/RCA) Q8I3Z9 (/RCA) Q8I3Z9 (/RCA) Q8I3Z9 (/RCA) Q8I3Z9 (/RCA) Q8I3Z9 (/RCA) Q8I3Z9 (/RCA) Q8I3Z9 (/RCA)
(5 more)