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CATH Superfamily 1.10.1220.10

Met repressor-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Met repressor-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Bifunctional protein PutA

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proline dehydrogenase activity GO:0004657
Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
 21 P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA)
(11 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
 21 P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA)
(11 more)
Bacterial-type proximal promoter sequence-specific DNA binding GO:0000986
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a bacterial gene (or cistron, or operon). The proximal promoter is in cis with and relatively close to the core promoter.
 11 P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA)
(1 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 11 P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA)
(1 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
 11 P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA)
(1 more)
1-pyrroline-5-carboxylate dehydrogenase activity GO:0003842
Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).
 11 P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA)
(1 more)
Proline dehydrogenase activity GO:0004657
Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
 11 P09546 (/IMP) P09546 (/IMP) P09546 (/IMP) P09546 (/IMP) P09546 (/IMP) P09546 (/IMP) P09546 (/IMP) P09546 (/IMP) P09546 (/IMP) P09546 (/IMP)
(1 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 11 P09546 (/IPI) P09546 (/IPI) P09546 (/IPI) P09546 (/IPI) P09546 (/IPI) P09546 (/IPI) P09546 (/IPI) P09546 (/IPI) P09546 (/IPI) P09546 (/IPI)
(1 more)
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
 11 P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA)
(1 more)
Proline oxidase activity GO:0051699
Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2.
 10 P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA)
1-pyrroline-5-carboxylate dehydrogenase activity GO:0003842
Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).
 2 Q87VC2 (/ISS) Q87VC2 (/ISS)
Proline dehydrogenase activity GO:0004657
Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
 2 Q87VC2 (/ISS) Q87VC2 (/ISS)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proline catabolic process to glutamate GO:0010133
The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate.
 11 P09546 (/IMP) P09546 (/IMP) P09546 (/IMP) P09546 (/IMP) P09546 (/IMP) P09546 (/IMP) P09546 (/IMP) P09546 (/IMP) P09546 (/IMP) P09546 (/IMP)
(1 more)
Proline catabolic process GO:0006562
The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
 10 P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA)
Proline transport GO:0015824
The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
 10 P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
 10 P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA)
Proline catabolic process GO:0006562
The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
 2 Q87VC2 (/ISS) Q87VC2 (/ISS)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
 11 P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA) P09546 (/IDA)
(1 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
 10 P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA)