The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Methyltransferase, alpha-helical capping domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Methyltransferase, alpha-helical capping domain

This superfamily includes the alpha-helical capping domain found in various methyltransferases, such as fatty acid O-methyltransferase (FAMT), salicylic acid carboxyl methyltransferase (SAMT), xanthosine (XR) methyltransferase (XMT), and 1,7-dimethylxanthine methyltransferase (DXMT). The capping domain is formed of alpha-helices and contains a binding cavity that accommodates fatty acid substrates with acyl chain lengths up to C12. This domain establishes specificity for the hydrophobic part of the substrate and is responsible for the substrate binding.


GO Diversity

Unique GO annotations
34 Unique GO terms

EC Diversity

Unique EC annotations
12 Unique EC terms

Species Diversity

Unique species annotations
542 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 12
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 2
Unique PDBs: 6
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 38
Unique EC: 12
Unique GO: 34
Unique Species: 542