The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"ACP-like
".
FunFam 3: Acyl carrier protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Holo-[acyl-carrier-protein] synthase activity GO:0008897
Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.
|
8 | Q7KWJ1 (/IDA) Q7KWJ1 (/IDA) Q7KWJ1 (/IDA) Q7KWJ1 (/IDA) Q7KWJ1 (/IDA) Q7KWJ1 (/IDA) Q7KWJ1 (/IDA) Q7KWJ1 (/IDA) |
|
Acyl carrier activity GO:0000036
Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis.
|
5 | P32463 (/ISS) P32463 (/ISS) P32463 (/ISS) P32463 (/ISS) P32463 (/ISS) |
|
Acyl carrier activity GO:0000036
Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis.
|
2 | P11943 (/IDA) P11943 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | O80800 (/IPI) |
|
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
|
1 | O80800 (/IDA) |
|
Cofactor binding GO:0048037
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
|
1 | Q10217 (/ISM) |
|
Cobalt ion binding GO:0050897
Interacting selectively and non-covalently with a cobalt (Co) ion.
|
1 | O80800 (/IDA) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Lipoate biosynthetic process GO:0009107
The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid.
|
5 | P32463 (/IMP) P32463 (/IMP) P32463 (/IMP) P32463 (/IMP) P32463 (/IMP) |
|
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
|
5 | P32463 (/IMP) P32463 (/IMP) P32463 (/IMP) P32463 (/IMP) P32463 (/IMP) |
|
Lipoate biosynthetic process GO:0009107
The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid.
|
2 | P11943 (/IDA) P11943 (/IDA) |
|
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
|
1 | P53665 (/IDA) |
|
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
|
1 | Q10217 (/ISS) |
|
[2Fe-2S] cluster assembly GO:0044571
The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.
|
1 | Q10217 (/ISO) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Apicoplast GO:0020011
The plastid organelle found in apicomplexans.
|
8 | Q7KWJ1 (/IDA) Q7KWJ1 (/IDA) Q7KWJ1 (/IDA) Q7KWJ1 (/IDA) Q7KWJ1 (/IDA) Q7KWJ1 (/IDA) Q7KWJ1 (/IDA) Q7KWJ1 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
6 | P32463 (/HDA) P32463 (/HDA) P32463 (/HDA) P32463 (/HDA) P32463 (/HDA) Q10217 (/HDA) |
|
Mitochondrial iron-sulfur cluster assembly complex GO:0099128
A protein complex consisting of frataxin, cysteine desulfurase, an accessory protein and a Fe-S scaffold protein. In human these genes correspond to FXN, NFS1, ISD11 and ISCU respectively. This complex assembles Fe-S clusters onto the scaffolding protein using the substrates ferrous iron, electrons, and sulfur from l-cysteine.
|
5 | P32463 (/IPI) P32463 (/IPI) P32463 (/IPI) P32463 (/IPI) P32463 (/IPI) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | O80800 (/IDA) P53665 (/IDA) |
|
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
2 | O80800 (/IDA) P53665 (/IDA) |
|
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
1 | Q10217 (/ISS) |