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CATH Superfamily 1.10.12.10

Lyase 2-enoyl-coa Hydratase, Chain A, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Lyase 2-enoyl-coa Hydratase, Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Probable enoyl-CoA hydratase, mitochondrial

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Enoyl-CoA hydratase. [EC: 4.2.1.17]
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O.
  • Acts in the reverse direction.
  • With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74).
 1139 A0A027ZP28 A0A027ZP28 A0A027ZP28 A0A027ZP28 A0A027ZP28 A0A027ZP28 A0A027ZP28 A0A027ZP28 A0A027ZP28 A0A027ZP28
(1129 more...)
Methylglutaconyl-CoA hydratase. [EC: 4.2.1.18]
(S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O.
    		 4 F1LU71 Q13825 Q54HG7 Q9JLZ3
    3-hydroxypropionyl-CoA dehydratase. [EC: 4.2.1.116]
    3-hydroxypropanoyl-CoA = acryloyl-CoA + H(2)O.
    • Catalyzes a step in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea.
    • The enzyme from Metallosphaera sedula acts nearly equally as well on (S)-3-hydroxybutanoyl-CoA but not (R)-3-hydroxybutanoyl-CoA.
    		 4 A0A088E6T0 A0A088E6T0 A4YI89 A4YI89
    Itaconyl-CoA hydratase. [EC: 4.2.1.56]
    Citramalyl-CoA = itaconyl-CoA + H(2)O.
      		 3 F1LU71 Q13825 Q9JLZ3