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CATH Superfamily 1.10.1070.11

Phosphatidylinositol 3-/4-kinase, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-/4-kinase, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 105 A0A024R3C7 A0A024R720 A0A096MY63 A0A0B0EBB5 A0A0D9RKI4 A0A0G2K344 A0A178WN52 A0A1I9FYX4 A0A1L8GAP7 A0A2K5IJ73
(95 more...)
Phosphatidylinositol-4,5-bisphosphate 3-kinase. [EC: 2.7.1.153]
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
  • This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
 42 A0A024R720 A0A096MY63 A0A0D9RKI4 A0A0G2K344 A0A2K5IJ73 A0A2K5YVM5 A0A2K6C9I6 A0A2K8FKV1 A0A2R9AJY1 A0A2U3VSW6
(32 more...)
1-phosphatidylinositol 4-kinase. [EC: 2.7.1.67]
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo- inositol 4-phosphate.
    		 35 A0A178UGA7 A0A1S6GWJ7 A4IID4 A9X1A0 B0KWC1 B1MTG7 B2KI64 B3EX61 B3LPA6 B4UT09
    (25 more...)
    Phosphatidylinositol 3-kinase. [EC: 2.7.1.137]
    ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo- inositol 3-phosphate.
      		 31 A0A1L8I323 A0A2I2ZRM9 A0A2I3SV31 A0A2R9AAE5 A7A1C3 B3RHC5 C7GQZ6 C8ZDK3 G2WJ66 G5EDY0
      (21 more...)
      Phosphatidylinositol-4-phosphate 3-kinase. [EC: 2.7.1.154]
      ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl- 1D-myo-inositol 3,4-bisphosphate.
      • This enzyme also phosphorylates PtdIns to PtdIns3P.
      		 9 A2RUF7 L7RRS0 O00443 O00750 O70167 O70173 O75747 Q5RAY1 Q61194
      Protein-tyrosine-phosphatase. [EC: 3.1.3.48]
      Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
      • Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
      		 1 Q75QN6
      Protein-serine/threonine phosphatase. [EC: 3.1.3.16]
      [a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
      • A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48).
      • The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).
      		 1 Q75QN6