The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Arf Nucleotide-binding Site Opener,domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Golgi-specific brefeldin A-resistance guanine nucl...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
ARF guanyl-nucleotide exchange factor activity GO:0005086
Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
3 A0A0B4K7N0 (/IGI) A1Z8W8 (/IGI) A1Z8W9 (/IGI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q6DFZ1 (/IPI) Q92538 (/IPI)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q92538 (/TAS)
ARF guanyl-nucleotide exchange factor activity GO:0005086
Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q9P7R8 (/ISO)
ARF guanyl-nucleotide exchange factor activity GO:0005086
Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q92538 (/TAS)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
1 Q92538 (/IDA)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
1 A1Z8W8 (/IPI)
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
1 Q92538 (/IDA)

There are 54 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
4 A0A0B4K7N0 (/IMP) A1Z8W8 (/IMP) A1Z8W9 (/IMP) Q92538 (/IMP)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
3 A0A0B4K7N0 (/IMP) A1Z8W8 (/IMP) A1Z8W9 (/IMP)
Epithelial cell development GO:0002064
The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
3 A0A0B4K7N0 (/IDA) A1Z8W8 (/IDA) A1Z8W9 (/IDA)
Salivary gland development GO:0007431
The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
3 A0A0B4K7N0 (/IDA) A1Z8W8 (/IDA) A1Z8W9 (/IDA)
Protein secretion GO:0009306
The controlled release of proteins from a cell.
3 A0A0B4K7N0 (/IMP) A1Z8W8 (/IMP) A1Z8W9 (/IMP)
Regulation of ARF protein signal transduction GO:0032012
Any process that modulates the frequency, rate or extent of ARF protein signal transduction.
3 A0A0B4K7N0 (/IC) A1Z8W8 (/IC) A1Z8W9 (/IC)
Secretion by cell GO:0032940
The controlled release of a substance by a cell.
3 A0A0B4K7N0 (/IDA) A1Z8W8 (/IDA) A1Z8W9 (/IDA)
Lumen formation, open tracheal system GO:0035149
Creation of the central hole of a tube in an open tracheal system through which gases flow.
3 A0A0B4K7N0 (/IDA) A1Z8W8 (/IDA) A1Z8W9 (/IDA)
Regulation of tube diameter, open tracheal system GO:0035158
Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size.
3 A0A0B4K7N0 (/IMP) A1Z8W8 (/IMP) A1Z8W9 (/IMP)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
3 A0A0B4K7N0 (/IGI) A1Z8W8 (/IGI) A1Z8W9 (/IGI)
Cell activation involved in immune response GO:0002263
A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890
The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Golgi to endosome transport GO:0006895
The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Protein localization to Golgi apparatus GO:0034067
A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Retrograde transport, endosome to Golgi GO:0042147
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
COPI coating of Golgi vesicle GO:0048205
The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Establishment of monopolar cell polarity GO:0061162
The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Protein localization to endoplasmic reticulum exit site GO:0070973
A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Golgi disassembly GO:0090166
A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Endoplasmic reticulum-Golgi intermediate compartment organization GO:0097111
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Cellular response to virus GO:0098586
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Reactive oxygen species biosynthetic process GO:1903409
The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Protein localization to endoplasmic reticulum tubular network GO:1903420
A process in which a protein is transported to, or maintained in, a location within an endoplasmic reticulum tubular network.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Regulation of protein localization to cell surface GO:2000008
Any process that modulates the frequency, rate or extent of protein localization to the cell surface.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Cell activation involved in immune response GO:0002263
A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
1 Q92538 (/IMP)
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
1 Q9P7R8 (/ISO)
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
1 Q92538 (/TAS)
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890
The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.
1 Q92538 (/IMP)
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890
The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.
1 Q92538 (/TAS)
Post-Golgi vesicle-mediated transport GO:0006892
The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.
1 Q92538 (/TAS)
Golgi to endosome transport GO:0006895
The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes.
1 Q92538 (/IMP)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
1 G5EGS5 (/IMP)
Endoplasmic reticulum organization GO:0007029
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
1 G5EGS5 (/IMP)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
1 Q92538 (/IMP)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
1 G5EGS5 (/IMP)
Signaling GO:0023052
The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
1 Q9P7R8 (/NAS)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q9P7R8 (/ISO)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
1 Q92538 (/IMP)
Protein localization to Golgi apparatus GO:0034067
A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.
1 Q92538 (/IMP)
Retrograde transport, endosome to Golgi GO:0042147
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
1 Q92538 (/IMP)
Golgi to plasma membrane protein transport GO:0043001
The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
1 Q9P7R8 (/IMP)
Secretion GO:0046903
The controlled release of a substance by a cell or a tissue.
1 G5EGS5 (/IMP)
COPI coating of Golgi vesicle GO:0048205
The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat.
1 Q92538 (/IMP)
Establishment of monopolar cell polarity GO:0061162
The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis.
1 Q92538 (/IMP)
Protein localization to endoplasmic reticulum exit site GO:0070973
A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site.
1 Q92538 (/IMP)
Golgi disassembly GO:0090166
A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance.
1 Q92538 (/IMP)
Endoplasmic reticulum-Golgi intermediate compartment organization GO:0097111
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment.
1 Q92538 (/IMP)
Cellular response to virus GO:0098586
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q92538 (/IMP)
Reactive oxygen species biosynthetic process GO:1903409
The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.
1 Q92538 (/IMP)
Protein localization to endoplasmic reticulum tubular network GO:1903420
A process in which a protein is transported to, or maintained in, a location within an endoplasmic reticulum tubular network.
1 Q92538 (/IMP)
Regulation of protein localization to cell surface GO:2000008
Any process that modulates the frequency, rate or extent of protein localization to the cell surface.
1 Q92538 (/IMP)

There are 25 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cis-Golgi network GO:0005801
The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.
6 A0A0B4K7N0 (/IDA) A0A0G2K3N1 (/IDA) A1Z8W8 (/IDA) A1Z8W9 (/IDA) F1M8X9 (/IDA) Q92538 (/IDA)
Golgi cis cisterna GO:0000137
The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.
4 A0A0B4K7N0 (/IDA) A1Z8W8 (/IDA) A1Z8W9 (/IDA) G5EGS5 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 A0A0G2K3N1 (/IDA) F1M8X9 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
2 A0A0G2K3N1 (/IDA) F1M8X9 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
2 A0A0G2K3N1 (/IDA) F1M8X9 (/IDA)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Endoplasmic reticulum-Golgi intermediate compartment GO:0005793
A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 Q92538 (/IDA) Q9P7R8 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Golgi stack GO:0005795
The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
2 A0A0G2K3N1 (/IDA) F1M8X9 (/IDA)
Golgi stack GO:0005795
The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Cis-Golgi network GO:0005801
The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
2 Q6A099 (/ISO) Q6DFZ1 (/ISO)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 Q92538 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9P7R8 (/HDA)
Endoplasmic reticulum-Golgi intermediate compartment GO:0005793
A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
1 Q92538 (/IDA)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
1 Q92538 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9P7R8 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q92538 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q92538 (/HDA)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
1 Q92538 (/IDA)
Endoplasmic reticulum exit site GO:0070971
An endoplasmic reticulum part at which COPII-coated vesicles are produced.
1 G5EGS5 (/IDA)