The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 387: Replication termination factor 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
6 Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
5 P21538 (/IDA) P21538 (/IDA) P21538 (/IDA) P21538 (/IDA) P21538 (/IDA)
Mating type region replication fork barrier binding GO:1990943
Interacting selectively and non-covalently with the replication fork barrier found in the mating type region of fission yeast.
1 Q9UUI6 (/IDA)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromatin silencing at rDNA GO:0000183
Repression of transcription of ribosomal DNA by altering the structure of chromatin.
6 Q12457 (/IMP) Q12457 (/IMP) Q12457 (/IMP) Q12457 (/IMP) Q12457 (/IMP) Q12457 (/IMP)
Termination of RNA polymerase I transcription GO:0006363
The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit.
6 Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA)
Termination of RNA polymerase I transcription GO:0006363
The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit.
6 Q12457 (/IMP) Q12457 (/IMP) Q12457 (/IMP) Q12457 (/IMP) Q12457 (/IMP) Q12457 (/IMP)
Negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging GO:1900008
Any process that stops, prevents or reduces the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging.
6 Q12457 (/IMP) Q12457 (/IMP) Q12457 (/IMP) Q12457 (/IMP) Q12457 (/IMP) Q12457 (/IMP)
Transcriptional start site selection at RNA polymerase II promoter GO:0001174
Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
5 P21538 (/IDA) P21538 (/IDA) P21538 (/IDA) P21538 (/IDA) P21538 (/IDA)
Transcriptional start site selection at RNA polymerase II promoter GO:0001174
Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
5 P21538 (/IMP) P21538 (/IMP) P21538 (/IMP) P21538 (/IMP) P21538 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
5 P21538 (/IMP) P21538 (/IMP) P21538 (/IMP) P21538 (/IMP) P21538 (/IMP)
Termination of RNA polymerase I transcription GO:0006363
The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit.
5 P21538 (/TAS) P21538 (/TAS) P21538 (/TAS) P21538 (/TAS) P21538 (/TAS)
Termination of RNA polymerase II transcription GO:0006369
The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed.
5 P21538 (/IMP) P21538 (/IMP) P21538 (/IMP) P21538 (/IMP) P21538 (/IMP)
Site-specific DNA replication termination at RTS1 barrier GO:0071171
A DNA replication termination process that takes place at the RTS1 termination site in the mating type locus, in a specific direction required for subsequent imprinting and mating-type switching.
1 Q9UUI6 (/IGI)
Site-specific DNA replication termination at RTS1 barrier GO:0071171
A DNA replication termination process that takes place at the RTS1 termination site in the mating type locus, in a specific direction required for subsequent imprinting and mating-type switching.
1 Q9UUI6 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
6 Q12457 (/HDA) Q12457 (/HDA) Q12457 (/HDA) Q12457 (/HDA) Q12457 (/HDA) Q12457 (/HDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
6 Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA)
RDNA heterochromatin GO:0033553
A region of heterochromatin located at the rDNA repeats in a chromosome.
6 Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA) Q12457 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 P21538 (/IDA) P21538 (/IDA) P21538 (/IDA) P21538 (/IDA) P21538 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9UUI6 (/HDA)