The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 105: Zinc finger E-box binding homeobox 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 O60315 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 O60315 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 O60315 (/NAS)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 O60315 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q9R0G7 (/ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q9R0G7 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 O60315 (/IPI)
Phosphatase regulator activity GO:0019208
Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
1 O60315 (/NAS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 O60315 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q9R0G7 (/ISO)
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
1 Q9R0G7 (/IDA)

There are 42 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
11 A0A0R4IWE5 (/IMP) A0A286Y942 (/IMP) A0A2R8QDL5 (/IMP) A0A2R8QLF5 (/IMP) A0A2R8RT96 (/IMP) B0LVE9 (/IMP) B0LVF0 (/IMP) B5DE38 (/IMP) F1QY45 (/IMP) F1R6J7 (/IMP)
(1 more)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
10 A0A0R4IWE5 (/IGI) A0A286Y942 (/IGI) A0A2R8QDL5 (/IGI) A0A2R8QLF5 (/IGI) A0A2R8RT96 (/IGI) B0LVE9 (/IGI) B0LVF0 (/IGI) B5DE38 (/IGI) F1QY45 (/IGI) F1R6J7 (/IGI)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
10 A0A0R4IWE5 (/IGI) A0A286Y942 (/IGI) A0A2R8QDL5 (/IGI) A0A2R8QLF5 (/IGI) A0A2R8RT96 (/IGI) B0LVE9 (/IGI) B0LVF0 (/IGI) B5DE38 (/IGI) F1QY45 (/IGI) F1R6J7 (/IGI)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
10 A0A0R4IWE5 (/IMP) A0A286Y942 (/IMP) A0A2R8QDL5 (/IMP) A0A2R8QLF5 (/IMP) A0A2R8RT96 (/IMP) B0LVE9 (/IMP) B0LVF0 (/IMP) B5DE38 (/IMP) F1QY45 (/IMP) F1R6J7 (/IMP)
Neural crest formation GO:0014029
The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.
10 A0A0R4IWE5 (/IGI) A0A286Y942 (/IGI) A0A2R8QDL5 (/IGI) A0A2R8QLF5 (/IGI) A0A2R8RT96 (/IGI) B0LVE9 (/IGI) B0LVF0 (/IGI) B5DE38 (/IGI) F1QY45 (/IGI) F1R6J7 (/IGI)
Neural crest formation GO:0014029
The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.
10 A0A0R4IWE5 (/IMP) A0A286Y942 (/IMP) A0A2R8QDL5 (/IMP) A0A2R8QLF5 (/IMP) A0A2R8RT96 (/IMP) B0LVE9 (/IMP) B0LVF0 (/IMP) B5DE38 (/IMP) F1QY45 (/IMP) F1R6J7 (/IMP)
Convergent extension involved in axis elongation GO:0060028
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.
10 A0A0R4IWE5 (/IGI) A0A286Y942 (/IGI) A0A2R8QDL5 (/IGI) A0A2R8QLF5 (/IGI) A0A2R8RT96 (/IGI) B0LVE9 (/IGI) B0LVF0 (/IGI) B5DE38 (/IGI) F1QY45 (/IGI) F1R6J7 (/IGI)
Dorsal convergence GO:0060030
The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement.
10 A0A0R4IWE5 (/IGI) A0A286Y942 (/IGI) A0A2R8QDL5 (/IGI) A0A2R8QLF5 (/IGI) A0A2R8RT96 (/IGI) B0LVE9 (/IGI) B0LVF0 (/IGI) B5DE38 (/IGI) F1QY45 (/IGI) F1R6J7 (/IGI)
Negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037
Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
6 A0A286Y942 (/IMP) A0A2R8QLF5 (/IMP) A0A2R8RT96 (/IMP) B0LVE9 (/IMP) B5DE38 (/IMP) F1QY45 (/IMP)
Dorsal convergence GO:0060030
The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement.
6 A0A286Y942 (/IMP) A0A2R8QLF5 (/IMP) A0A2R8RT96 (/IMP) B0LVE9 (/IMP) B5DE38 (/IMP) F1QY45 (/IMP)
Fibroblast growth factor receptor signaling pathway involved in somitogenesis GO:0090243
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to somitogenesis.
6 A0A286Y942 (/IMP) A0A2R8QLF5 (/IMP) A0A2R8RT96 (/IMP) B0LVE9 (/IMP) B5DE38 (/IMP) F1QY45 (/IMP)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
5 A0A0R4IWE5 (/IMP) A0A2R8QDL5 (/IMP) B0LVF0 (/IMP) F1R6J7 (/IMP) Q9R0G7 (/IMP)
Intrahepatic bile duct development GO:0035622
The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver).
4 A0A0R4IWE5 (/IMP) A0A2R8QDL5 (/IMP) B0LVF0 (/IMP) F1R6J7 (/IMP)
Convergent extension involved in axis elongation GO:0060028
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.
4 A0A0R4IWE5 (/IMP) A0A2R8QDL5 (/IMP) B0LVF0 (/IMP) F1R6J7 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 O60315 (/IMP) Q9R0G7 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 O60315 (/IMP) Q9R0G7 (/IMP)
Positive regulation of melanin biosynthetic process GO:0048023
Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
2 O60315 (/IC) Q9R0G7 (/IC)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 O60315 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9R0G7 (/ISO)
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
1 Q9R0G7 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 O60315 (/NAS)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 Q9R0G7 (/IGI)
Corpus callosum morphogenesis GO:0021540
The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres.
1 Q9R0G7 (/IMP)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
1 Q9R0G7 (/IMP)
Cell proliferation in forebrain GO:0021846
The creation of greater cell numbers in the forebrain due to cell division of progenitor cells.
1 Q9R0G7 (/IMP)
Corticospinal tract morphogenesis GO:0021957
Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract.
1 Q9R0G7 (/IMP)
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
1 Q9R0G7 (/IMP)
Positive regulation of JUN kinase activity GO:0043507
Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
1 Q9R0G7 (/IMP)
Positive regulation of melanocyte differentiation GO:0045636
Any process that activates or increases the frequency, rate or extent of melanocyte differentiation.
1 Q9R0G7 (/IMP)
Positive regulation of melanocyte differentiation GO:0045636
Any process that activates or increases the frequency, rate or extent of melanocyte differentiation.
1 O60315 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q9R0G7 (/ISO)
Developmental pigmentation GO:0048066
The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.
1 Q9R0G7 (/IMP)
Developmental pigmentation GO:0048066
The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.
1 O60315 (/ISS)
Embryonic morphogenesis GO:0048598
The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
1 Q9R0G7 (/IGI)
Collateral sprouting GO:0048668
The process in which outgrowths develop from the shafts of existing axons.
1 Q9R0G7 (/IMP)
Positive regulation of axonogenesis GO:0050772
Any process that activates or increases the frequency, rate or extent of axonogenesis.
1 Q9R0G7 (/IMP)
Mammillary axonal complex development GO:0061373
The progression of the mammillary axonal complex over time, from its formation to the mature structure. The mammillary axonal complex is formed by the axons from the lateral, medial mammillary and the dorsal premammillary nuclei which share a branching pattern. Every neuron gives off one axonal stem that bifurcates into 2 branches. One of the branches is directed dorsally to the thalamus and another caudally to the midbrain.
1 Q9R0G7 (/IMP)
Melanocyte migration GO:0097324
The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.
1 Q9R0G7 (/IMP)
Melanocyte migration GO:0097324
The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.
1 O60315 (/ISS)
Positive regulation of lens fiber cell differentiation GO:1902748
Any process that activates or increases the frequency, rate or extent of lens fiber cell differentiation.
1 Q9R0G7 (/IMP)
Regulation of melanosome organization GO:1903056
Any process that modulates the frequency, rate or extent of melanosome organization.
1 Q9R0G7 (/IMP)
Regulation of melanosome organization GO:1903056
Any process that modulates the frequency, rate or extent of melanosome organization.
1 O60315 (/ISS)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 A0A1B0GV02 (/IDA) A0A1B0GVV8 (/IDA) A0A1B0GW50 (/IDA) A0A1B0GWI0 (/IDA) A0JP08 (/IDA) O60315 (/IDA) Q9R0G7 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
6 A0A1B0GV02 (/IDA) A0A1B0GVV8 (/IDA) A0A1B0GW50 (/IDA) A0A1B0GWI0 (/IDA) A0JP08 (/IDA) O60315 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 A0A1B0GV02 (/IDA) A0A1B0GVV8 (/IDA) A0A1B0GW50 (/IDA) A0A1B0GWI0 (/IDA) A0JP08 (/IDA) O60315 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 O60315 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q9R0G7 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9R0G7 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9R0G7 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9R0G7 (/ISO)