The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeo-prospero domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Prospero homeobox 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P34522 (/ISS)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P29617 (/IMP)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P29617 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P29617 (/IMP)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P29617 (/NAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P29617 (/TAS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 P29617 (/IDA)

There are 60 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lymphangiogenesis GO:0001946
Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
2 A0A0R4IRB6 (/IGI) D2DHG1 (/IGI)
Lymphangiogenesis GO:0001946
Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
2 A0A0R4IRB6 (/IMP) D2DHG1 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P29617 (/IMP)
Cell fate specification GO:0001708
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
1 P29617 (/TAS)
Eye photoreceptor cell differentiation GO:0001754
The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.
1 P29617 (/TAS)
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
1 P29617 (/IGI)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P29617 (/TAS)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P34522 (/ISS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 P29617 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 P29617 (/TAS)
Neuroblast fate determination GO:0007400
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.
1 P29617 (/NAS)
Neuroblast fate determination GO:0007400
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.
1 P29617 (/TAS)
Ganglion mother cell fate determination GO:0007402
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed.
1 P29617 (/IMP)
Ganglion mother cell fate determination GO:0007402
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed.
1 P29617 (/TAS)
Neuroblast proliferation GO:0007405
The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
1 P29617 (/IMP)
Negative regulation of neuroblast proliferation GO:0007406
Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts.
1 P29617 (/IMP)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
1 P29617 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 P29617 (/IMP)
Synapse assembly GO:0007416
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
1 P29617 (/IMP)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 P29617 (/IMP)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 P29617 (/TAS)
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
1 P29617 (/TAS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P29617 (/IMP)
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
1 P29617 (/IMP)
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
1 P29617 (/TAS)
Sensory organ development GO:0007423
The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.
1 P29617 (/TAS)
R7 cell fate commitment GO:0007465
The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium.
1 P29617 (/IMP)
R7 cell fate commitment GO:0007465
The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium.
1 P29617 (/TAS)
Courtship behavior GO:0007619
The behavioral interactions between organisms for the purpose of attracting sexual partners.
1 P29617 (/TAS)
Male courtship behavior GO:0008049
The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster.
1 P29617 (/IMP)
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
1 P29617 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P29617 (/IMP)
Asymmetric cell division GO:0008356
The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.
1 P29617 (/TAS)
Glial cell differentiation GO:0010001
The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.
1 P29617 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P29617 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P29617 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P29617 (/IMP)
Neuroblast differentiation GO:0014016
The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts.
1 P29617 (/IMP)
Regulation of retinal cone cell fate specification GO:0042673
Any process that mediates the specification of a cell into a retinal cone cell.
1 P29617 (/IGI)
Regulation of retinal cone cell fate specification GO:0042673
Any process that mediates the specification of a cell into a retinal cone cell.
1 P29617 (/IMP)
Compound eye cone cell fate commitment GO:0042676
The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type.
1 P29617 (/TAS)
Cell dedifferentiation GO:0043697
The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.
1 P29617 (/IGI)
Cell fate commitment GO:0045165
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
1 P29617 (/IMP)
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
1 P29617 (/IGI)
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
1 P29617 (/IMP)
Regulation of R7 cell differentiation GO:0045676
Any process that modulates the frequency, rate or extent of R7 differentiation.
1 P29617 (/IGI)
Regulation of R7 cell differentiation GO:0045676
Any process that modulates the frequency, rate or extent of R7 differentiation.
1 P29617 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P29617 (/IDA)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
1 P29617 (/IMP)
Negative regulation of axonogenesis GO:0050771
Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis.
1 P29617 (/IMP)
Sensory perception of taste GO:0050909
The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.
1 P29617 (/IMP)
Regulation of DNA-binding transcription factor activity GO:0051090
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 P29617 (/IDA)
Asymmetric neuroblast division GO:0055059
The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials.
1 P29617 (/IMP)
Asymmetric neuroblast division resulting in ganglion mother cell formation GO:0055060
Any process resulting in the physical partitioning and separation of a neuroblast into a neuroblast and a ganglion mother cell.
1 P29617 (/IMP)
Axonogenesis involved in innervation GO:0060385
The neurite development process that generates a long process of a neuron, as it invades a target tissue.
1 P29617 (/IMP)
Axon development GO:0061564
The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation).
1 P29617 (/IMP)
G1 to G0 transition GO:0070314
A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence.
1 P29617 (/IMP)
Dendrite guidance GO:0070983
The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues.
1 P29617 (/IMP)
Regulation of protein localization to nucleus GO:1900180
Any process that modulates the frequency, rate or extent of protein localization to nucleus.
1 P29617 (/IMP)
Regulation of neuroblast proliferation GO:1902692
Any process that modulates the frequency, rate or extent of neuroblast proliferation.
1 P29617 (/IGI)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P29617 (/NAS) P34522 (/NAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P29617 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P29617 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P29617 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 P29617 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 P29617 (/TAS)
Basal part of cell GO:0045178
The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
1 P29617 (/NAS)
Basal part of cell GO:0045178
The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
1 P29617 (/TAS)
Apical cortex GO:0045179
The region that lies just beneath the plasma membrane on the apical edge of a cell.
1 P29617 (/IDA)
Basal cortex GO:0045180
The region that lies just beneath the plasma membrane on the basal edge of a cell.
1 P29617 (/IDA)
Basal cortex GO:0045180
The region that lies just beneath the plasma membrane on the basal edge of a cell.
1 P29617 (/NAS)