The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 93: Putative interferon regulatory factor 6

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
16 O14896 (/IPI) O14896 (/IPI) O14896 (/IPI) O14896 (/IPI) O14896 (/IPI) O14896 (/IPI) O14896 (/IPI) O14896 (/IPI) O14896 (/IPI) O14896 (/IPI)
(6 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
13 O14896 (/ISA) O14896 (/ISA) O14896 (/ISA) O14896 (/ISA) O14896 (/ISA) O14896 (/ISA) O14896 (/ISA) O14896 (/ISA) O14896 (/ISA) O14896 (/ISA)
(3 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
13 O14896 (/ISM) O14896 (/ISM) O14896 (/ISM) O14896 (/ISM) O14896 (/ISM) O14896 (/ISM) O14896 (/ISM) O14896 (/ISM) O14896 (/ISM) O14896 (/ISM)
(3 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
13 O14896 (/NAS) O14896 (/NAS) O14896 (/NAS) O14896 (/NAS) O14896 (/NAS) O14896 (/NAS) O14896 (/NAS) O14896 (/NAS) O14896 (/NAS) O14896 (/NAS)
(3 more)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
13 O14896 (/IC) O14896 (/IC) O14896 (/IC) O14896 (/IC) O14896 (/IC) O14896 (/IC) O14896 (/IC) O14896 (/IC) O14896 (/IC) O14896 (/IC)
(3 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
13 O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS)
(3 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
13 O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS)
(3 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
12 O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA)
(2 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
3 P56477 (/ISO) P56477 (/ISO) P97431 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P56477 (/ISO) P56477 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P97431 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P97431 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q13568 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q13568 (/IMP)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
13 O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS)
(3 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
13 O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA)
(3 more)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
13 O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS)
(3 more)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
13 O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS)
(3 more)
Mammary gland epithelial cell differentiation GO:0060644
The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland.
13 O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS) O14896 (/ISS)
(3 more)
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
12 O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA)
(2 more)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
12 O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA)
(2 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P56477 (/ISO) P56477 (/ISO) P97431 (/ISO)
Response to peptidoglycan GO:0032494
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.
2 P56477 (/ISO) P56477 (/ISO)
Response to muramyl dipeptide GO:0032495
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
2 P56477 (/ISO) P56477 (/ISO)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2 P56477 (/ISO) P56477 (/ISO)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
2 P56477 (/IMP) P56477 (/IMP)
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
1 P97431 (/ISO)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P97431 (/IGI)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P97431 (/ISO)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q08DD6 (/ISS)
Keratinocyte differentiation GO:0030216
The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
1 P97431 (/IMP)
Response to peptidoglycan GO:0032494
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.
1 Q13568 (/IDA)
Response to muramyl dipeptide GO:0032495
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
1 Q13568 (/IDA)
Positive regulation of interferon-alpha production GO:0032727
Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
1 Q13568 (/IC)
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
1 Q13568 (/IC)
Positive regulation of interleukin-12 production GO:0032735
Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
1 Q13568 (/IC)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q13568 (/IMP)
Skin development GO:0043588
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
1 P97431 (/IGI)
Skin development GO:0043588
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
1 P97431 (/IMP)
Keratinocyte proliferation GO:0043616
The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin.
1 P97431 (/IGI)
Keratinocyte proliferation GO:0043616
The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin.
1 P97431 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P97431 (/IDA)
Cell development GO:0048468
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
1 P97431 (/IMP)
Embryonic neurocranium morphogenesis GO:0048702
The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain.
1 Q6PGZ7 (/IMP)
Roof of mouth development GO:0060021
The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.
1 P97431 (/IMP)
Epithelium development GO:0060429
The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
1 Q6PGZ7 (/IMP)
Mammary gland epithelial cell differentiation GO:0060644
The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland.
1 P97431 (/IEP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
28 B1AJU4 (/IDA) B1AJU4 (/IDA) B1AJU4 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA)
(18 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
27 B1AJU4 (/IDA) B1AJU4 (/IDA) B1AJU4 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA)
(17 more)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
27 B1AJU4 (/IDA) B1AJU4 (/IDA) B1AJU4 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA) G0Z349 (/IDA)
(17 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
13 O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA) O14896 (/IDA)
(3 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS) O14896 (/TAS)
(3 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
12 O14896 (/HDA) O14896 (/HDA) O14896 (/HDA) O14896 (/HDA) O14896 (/HDA) O14896 (/HDA) O14896 (/HDA) O14896 (/HDA) O14896 (/HDA) O14896 (/HDA)
(2 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P56477 (/ISO) P56477 (/ISO) P97431 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P56477 (/ISO) P56477 (/ISO) P97431 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P97431 (/ISS) Q08DD6 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P97431 (/ISO)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
1 P97431 (/ISO)