The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 69: Paired box protein Pax-6

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 43 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
58 A0A0R4IQL7 (/IDA) L0MPR7 (/IDA) O18381 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA)
(48 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
53 P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS)
(43 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
52 G5EDS1 (/IPI) O18381 (/IPI) P26367 (/IPI) P26367 (/IPI) P26367 (/IPI) P26367 (/IPI) P26367 (/IPI) P26367 (/IPI) P26367 (/IPI) P26367 (/IPI)
(42 more)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
50 P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA)
(40 more)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
27 P32115 (/IDA) P32115 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA)
(17 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
27 P32115 (/IDA) P32115 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA)
(17 more)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
27 P32115 (/ISO) P32115 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(17 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
27 P26630 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA)
(17 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
26 O43316 (/ISA) P26367 (/ISA) P26367 (/ISA) P26367 (/ISA) P26367 (/ISA) P26367 (/ISA) P26367 (/ISA) P26367 (/ISA) P26367 (/ISA) P26367 (/ISA)
(16 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
26 O43316 (/ISM) P26367 (/ISM) P26367 (/ISM) P26367 (/ISM) P26367 (/ISM) P26367 (/ISM) P26367 (/ISM) P26367 (/ISM) P26367 (/ISM) P26367 (/ISM)
(16 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
26 O43316 (/NAS) P26367 (/NAS) P26367 (/NAS) P26367 (/NAS) P26367 (/NAS) P26367 (/NAS) P26367 (/NAS) P26367 (/NAS) P26367 (/NAS) P26367 (/NAS)
(16 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
26 O43316 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS)
(16 more)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
25 P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA)
(15 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
25 P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA)
(15 more)
AT DNA binding GO:0003680
Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA).
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
25 P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA)
(15 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
25 P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA)
(15 more)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
25 P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI)
(15 more)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
25 P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS)
(15 more)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
25 P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI)
(15 more)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
25 P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS)
(15 more)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
25 P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI)
(15 more)
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
25 P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA)
(15 more)
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
25 P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS)
(15 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
25 P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA)
(15 more)
Co-SMAD binding GO:0070410
Interacting selectively and non-covalently with a common mediator SMAD signaling protein.
25 P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA)
(15 more)
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
25 P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA)
(15 more)
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
25 P26367 (/IPI) P26367 (/IPI) P26367 (/IPI) P26367 (/IPI) P26367 (/IPI) P26367 (/IPI) P26367 (/IPI) P26367 (/IPI) P26367 (/IPI) P26367 (/IPI)
(15 more)
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
HMG box domain binding GO:0071837
Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin.
25 P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI) P63015 (/IPI)
(15 more)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
4 L0MPR7 (/IMP) O18381 (/IMP) Q9V490 (/IMP) Q9XZC2 (/IMP)
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
3 O18381 (/IDA) P32115 (/IDA) P32115 (/IDA)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
3 Q1LZF1 (/ISS) Q1LZF1 (/ISS) Q1LZF1 (/ISS)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
2 O88436 (/IDA) P63016 (/IDA)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 O18381 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 P63016 (/IC)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P63016 (/IC)
AT DNA binding GO:0003680
Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA).
1 P63016 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 G5EDS1 (/ISS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 O18381 (/IMP)

There are 187 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
54 L0MPR7 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP)
(44 more)
Pancreatic A cell development GO:0003322
The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
51 P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP)
(41 more)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
51 P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP)
(41 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
51 O18381 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA)
(41 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
33 A0A0R4IQL7 (/IDA) L0MPR7 (/IDA) O18381 (/IDA) P26630 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA)
(23 more)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
30 A0A0R4IQL7 (/IMP) G5EDS1 (/IMP) P26630 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(20 more)
Type B pancreatic cell differentiation GO:0003309
The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
29 A0A0R4IQL7 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(19 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
29 L0MPR7 (/IMP) O18381 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(19 more)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
29 C7B0W6 (/IMP) F1R840 (/IMP) G2ZGB0 (/IMP) O18381 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP)
(19 more)
Positive regulation of core promoter binding GO:1904798
Any process that activates or increases the frequency, rate or extent of core promoter binding.
29 P63015 (/ISS) P63015 (/ISS) P63015 (/ISS) P63015 (/ISS) P63015 (/ISS) P63015 (/ISS) P63015 (/ISS) P63015 (/ISS) P63015 (/ISS) P63015 (/ISS)
(19 more)
Lens development in camera-type eye GO:0002088
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
28 A0A0R4IQL7 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(18 more)
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
28 O43316 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS)
(18 more)
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
28 P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS)
(18 more)
Cornea development in camera-type eye GO:0061303
The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye.
28 A0A0R4IQL7 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP)
(18 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
27 P32115 (/TAS) P32115 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS)
(17 more)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
27 O18381 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(17 more)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
26 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(16 more)
Habenula development GO:0021986
The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland.
26 P26630 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(16 more)
Cell fate commitment GO:0045165
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
26 G5EDS1 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(16 more)
Astrocyte differentiation GO:0048708
The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
26 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(16 more)
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
26 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(16 more)
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
25 P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP)
(15 more)
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Eye development GO:0001654
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
25 P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS)
(15 more)
Cell fate determination GO:0001709
A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Epithelial cell development GO:0002064
The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Regionalization GO:0003002
The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Type B pancreatic cell differentiation GO:0003309
The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Pancreatic A cell differentiation GO:0003310
The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Pancreatic A cell development GO:0003322
The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
25 P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA)
(15 more)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
25 P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS)
(15 more)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
25 P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS) P26367 (/TAS)
(15 more)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
25 P26367 (/IEP) P26367 (/IEP) P26367 (/IEP) P26367 (/IEP) P26367 (/IEP) P26367 (/IEP) P26367 (/IEP) P26367 (/IEP) P26367 (/IEP) P26367 (/IEP)
(15 more)
Regulation of asymmetric cell division GO:0009786
Any process that modulates the frequency, rate or extent of asymmetric cell division.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Dorsal/ventral axis specification GO:0009950
The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
25 P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI)
(15 more)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Positive regulation of cell death GO:0010942
Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Regulation of neuron projection development GO:0010975
Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Pallium development GO:0021543
The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Rhombomere morphogenesis GO:0021593
The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Olfactory bulb development GO:0021772
The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Oligodendrocyte cell fate specification GO:0021778
The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Cerebral cortex regionalization GO:0021796
The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Forebrain dorsal/ventral pattern formation GO:0021798
The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Commitment of neuronal cell to specific neuron type in forebrain GO:0021902
The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Forebrain-midbrain boundary formation GO:0021905
The process whose specific outcome is the creation of the forebrain-midbrain boundary.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification GO:0021912
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification GO:0021913
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment GO:0021918
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Telencephalon regionalization GO:0021978
The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Pituitary gland development GO:0021983
The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Interkinetic nuclear migration GO:0022027
The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Signal transduction involved in regulation of gene expression GO:0023019
Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.
25 P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA) P63015 (/IDA)
(15 more)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Keratinocyte differentiation GO:0030216
The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Positive regulation of epithelial cell differentiation GO:0030858
Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Hindbrain development GO:0030902
The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Lacrimal gland development GO:0032808
The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Protein localization to organelle GO:0033365
A process in which a protein is transported to, or maintained in, a location within an organelle.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Eye photoreceptor cell development GO:0042462
Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Positive regulation of cell fate specification GO:0042660
Any process that activates or enables a cell to adopt a specific fate.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
25 P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI)
(15 more)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Cell fate commitment GO:0045165
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
25 P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI)
(15 more)
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
25 P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI)
(15 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
25 P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP)
(15 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
25 P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI)
(15 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
25 P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS) P26367 (/ISS)
(15 more)
Regulation of timing of cell differentiation GO:0048505
The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Embryonic camera-type eye morphogenesis GO:0048596
The process in which the anatomical structures of the eye are generated and organized during embryonic development.
25 P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI)
(15 more)
Neuron fate commitment GO:0048663
The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.
25 P26367 (/NAS) P26367 (/NAS) P26367 (/NAS) P26367 (/NAS) P26367 (/NAS) P26367 (/NAS) P26367 (/NAS) P26367 (/NAS) P26367 (/NAS) P26367 (/NAS)
(15 more)
Astrocyte differentiation GO:0048708
The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
25 P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI) P63015 (/IGI)
(15 more)
Olfactory bulb mitral cell layer development GO:0061034
The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Iris morphogenesis GO:0061072
The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina.
25 P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP) P26367 (/IMP)
(15 more)
Iris morphogenesis GO:0061072
The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Cornea development in camera-type eye GO:0061303
The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Neural precursor cell proliferation GO:0061351
The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Positive regulation of glucagon secretion GO:0070094
Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Learned vocalization behavior or vocal learning GO:0098598
Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Positive regulation of glutamatergic neuron differentiation GO:0120008
Any process that activates or increases the frequency, rate or extent of glutamatergic neuron differentiation.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Insulin metabolic process GO:1901142
The chemical reactions and pathways involving insulin.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Positive regulation of core promoter binding GO:1904798
Any process that activates or increases the frequency, rate or extent of core promoter binding.
25 P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA)
(15 more)
Positive regulation of core promoter binding GO:1904798
Any process that activates or increases the frequency, rate or extent of core promoter binding.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Sensory neuron migration GO:1904937
The orderly movement of a sensory neuron from one site to another.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Cellular response to leukemia inhibitory factor GO:1990830
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
25 P63015 (/IEP) P63015 (/IEP) P63015 (/IEP) P63015 (/IEP) P63015 (/IEP) P63015 (/IEP) P63015 (/IEP) P63015 (/IEP) P63015 (/IEP) P63015 (/IEP)
(15 more)
Negative regulation of neural precursor cell proliferation GO:2000178
Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.
25 P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP) P63015 (/IMP)
(15 more)
Positive regulation of neuron migration GO:2001224
Any process that activates or increases the frequency, rate or extent of neuron migration.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Hindbrain development GO:0030902
The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).
5 A0A0R4IQL7 (/IMP) P26630 (/IMP) P63016 (/IMP) Q6DHA8 (/IMP) Q9YHZ8 (/IMP)
Pancreatic A cell differentiation GO:0003310
The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
4 A0A0R4IQL7 (/IMP) P63016 (/IMP) Q6DHA8 (/IMP) Q9YHZ8 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
4 A0A0R4IQL7 (/IGI) P26630 (/IGI) Q6DHA8 (/IGI) Q9YHZ8 (/IGI)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
4 L0MPR7 (/IMP) O18381 (/IMP) Q9V490 (/IMP) Q9XZC2 (/IMP)
Epithalamus development GO:0021538
The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle.
4 A0A0R4IQL7 (/IGI) P26630 (/IGI) Q6DHA8 (/IGI) Q9YHZ8 (/IGI)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 P63016 (/ISS) Q1LZF1 (/ISS) Q1LZF1 (/ISS) Q1LZF1 (/ISS)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
4 L0MPR7 (/TAS) O18381 (/TAS) Q9V490 (/TAS) Q9XZC2 (/TAS)
Brain morphogenesis GO:0048854
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
4 L0MPR7 (/IMP) O18381 (/IMP) Q9V490 (/IMP) Q9XZC2 (/IMP)
Eye development GO:0001654
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
3 A0A0R4IQL7 (/IMP) Q6DHA8 (/IMP) Q9YHZ8 (/IMP)
Lens morphogenesis in camera-type eye GO:0002089
The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
3 A0A0R4IQL7 (/IMP) Q6DHA8 (/IMP) Q9YHZ8 (/IMP)
Pancreatic D cell differentiation GO:0003311
The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin.
3 A0A0R4IQL7 (/IMP) Q6DHA8 (/IMP) Q9YHZ8 (/IMP)
Ocellus development GO:0008056
The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects.
3 L0MPR7 (/IGI) Q9V490 (/IGI) Q9XZC2 (/IGI)
Ocellus development GO:0008056
The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects.
3 L0MPR7 (/IMP) Q9V490 (/IMP) Q9XZC2 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
3 O18381 (/IMP) P26630 (/IMP) Q6DHA8 (/IMP)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
3 C7B0W6 (/IMP) F1R840 (/IMP) G2ZGB0 (/IMP)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
3 O43316 (/TAS) P32115 (/TAS) P32115 (/TAS)
Eye-antennal disc development GO:0035214
Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps.
3 L0MPR7 (/IMP) Q9V490 (/IMP) Q9XZC2 (/IMP)
Pancreatic epsilon cell differentiation GO:0090104
The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic epsilon cell. A pancreatic epsilon cell is a cell in the pancreas that secretes ghrelin.
3 A0A0R4IQL7 (/IMP) Q6DHA8 (/IMP) Q9YHZ8 (/IMP)
Pancreas regeneration GO:1990798
The regrowth of a destroyed pancreas.
3 C7B0W6 (/IMP) F1R840 (/IMP) G2ZGB0 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P32115 (/IDA) P32115 (/IDA)
Retinal cone cell differentiation GO:0042670
The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell.
2 P26630 (/IMP) Q6DHA8 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P32115 (/ISO) P32115 (/ISO)
Regulation of cell differentiation GO:0045595
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
2 P32115 (/IMP) P32115 (/IMP)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
2 P32115 (/IMP) P32115 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P32115 (/ISO) P32115 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 G5EDS1 (/IMP) O18381 (/IMP)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
2 O88436 (/IEP) P63016 (/IEP)
Retinal rod cell differentiation GO:0060221
The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell.
2 P26630 (/IMP) Q6DHA8 (/IMP)
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
1 O18381 (/IMP)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
1 P63016 (/IMP)
Epithelial cell development GO:0002064
The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
1 P63016 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 G5EDS1 (/ISS)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 P63016 (/IEP)
Eye-antennal disc morphogenesis GO:0007455
The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps.
1 O18381 (/TAS)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 O88436 (/IEP)
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
1 O18381 (/IMP)
Glial cell migration GO:0008347
The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
1 O18381 (/IMP)
Positive regulation of cell death GO:0010942
Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 P63016 (/IMP)
Regulation of neuron projection development GO:0010975
Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P63016 (/IGI)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
1 O18381 (/IEP)
Spinal cord development GO:0021510
The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.
1 P63016 (/IEP)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 P63016 (/IEP)
Rhombomere morphogenesis GO:0021593
The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.
1 P63016 (/IMP)
Olfactory bulb development GO:0021772
The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex.
1 P63016 (/IMP)
Interkinetic nuclear migration GO:0022027
The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle.
1 P63016 (/IMP)
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
1 G5EDS1 (/IMP)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 O18381 (/IMP)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
1 O18381 (/IMP)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
1 P26630 (/IGI)
Hindbrain development GO:0030902
The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).
1 P63016 (/IDA)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P63016 (/IEP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P63016 (/IEP)
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
1 O18381 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 O88436 (/IEP)
Positive regulation of cell fate specification GO:0042660
Any process that activates or enables a cell to adopt a specific fate.
1 P63016 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 O88436 (/IMP)
Regulation of insulin-like growth factor receptor signaling pathway GO:0043567
Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling.
1 O18381 (/IMP)
Photoreceptor cell fate specification GO:0043704
The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
1 O18381 (/IMP)
Cellular response to fibroblast growth factor stimulus GO:0044344
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
1 P63016 (/IEP)
Nematode male tail tip morphogenesis GO:0045138
The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome.
1 G5EDS1 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P63016 (/IEP)
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
1 P63016 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 O88436 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P63016 (/IC)
Central complex development GO:0048036
The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli.
1 O18381 (/IMP)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
1 O18381 (/IMP)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 O88436 (/IEP)
Olfactory bulb mitral cell layer development GO:0061034
The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer.
1 P63016 (/IMP)
Neural precursor cell proliferation GO:0061351
The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.
1 P63016 (/IMP)
Positive regulation of glucagon secretion GO:0070094
Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.
1 P63016 (/IMP)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 P63016 (/IEP)
Cellular response to prostaglandin E stimulus GO:0071380
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
1 P63016 (/IEP)
Learned vocalization behavior or vocal learning GO:0098598
Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned.
1 P63016 (/IMP)
Positive regulation of glutamatergic neuron differentiation GO:0120008
Any process that activates or increases the frequency, rate or extent of glutamatergic neuron differentiation.
1 P63016 (/IMP)
Insulin metabolic process GO:1901142
The chemical reactions and pathways involving insulin.
1 P63016 (/IMP)
Sensory neuron migration GO:1904937
The orderly movement of a sensory neuron from one site to another.
1 P63016 (/IMP)
Positive regulation of neuron migration GO:2001224
Any process that activates or increases the frequency, rate or extent of neuron migration.
1 P63016 (/IGI)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
80 E9PKM0 (/IDA) E9PKM0 (/IDA) E9PKM0 (/IDA) F1T0F8 (/IDA) F1T0F8 (/IDA) F1T0F8 (/IDA) F1T0F8 (/IDA) F1T0F8 (/IDA) F1T0F8 (/IDA) F1T0F8 (/IDA)
(70 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
80 E9PKM0 (/IDA) E9PKM0 (/IDA) E9PKM0 (/IDA) F1T0F8 (/IDA) F1T0F8 (/IDA) F1T0F8 (/IDA) F1T0F8 (/IDA) F1T0F8 (/IDA) F1T0F8 (/IDA) F1T0F8 (/IDA)
(70 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
56 G5EDS1 (/IDA) O42348 (/IDA) O42348 (/IDA) O88436 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA)
(46 more)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
51 P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA)
(41 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
28 O43316 (/TAS) P32115 (/TAS) P32115 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS)
(18 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
27 P32115 (/ISO) P32115 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(17 more)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
27 P32115 (/TAS) P32115 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS) P63015 (/TAS)
(17 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
26 G5EDS1 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA) P26367 (/IDA)
(16 more)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
25 P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO) P63015 (/ISO)
(15 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 A4GG24 (/ISS) A4GG24 (/ISS) A4GG26 (/ISS) A4GG27 (/ISS) A4GG27 (/ISS) A4GG27 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O18381 (/TAS)