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CATH Superfamily 1.10.10.10

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 473: Caffeic acid O-methyltransferase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Caffeate O-methyltransferase. [EC: 2.1.1.68]
S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L- homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate.
  • 3,4-dihydroxybenzaldehyde and catechol can act as acceptor, more slowly.
 8 A0A0E0QEJ7 A0A0E0QEJ7 Q06509 Q06509 Q5GLJ6 Q5GLJ6 Q6ZD89 Q6ZD89
Flavone 3'-O-methyltransferase. [EC: 2.1.1.42]
S-adenosyl-L-methionine + 3'-hydroxyflavone = S-adenosyl-L-homocysteine + 3'-methoxyflavone.
  • The enzyme prefers flavones with vicinal 3',4'-dihydroxyl groups.
 4 A0A0E0QEJ7 A0A0E0QEJ7 Q6ZD89 Q6ZD89
Acetylserotonin O-methyltransferase. [EC: 2.1.1.4]
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin.
  • Some other hydroxyindoles also act as acceptor, more slowly.
 4 A0A0E0QEJ7 A0A0E0QEJ7 Q6ZD89 Q6ZD89
Naringenin 7-O-methyltransferase. [EC: 2.1.1.232]
S-adenosyl-L-methionine + (2S)-naringenin = S-adenosyl-L-homocysteine + (2S)-sakuranetin.
  • The enzyme is involved in the biosynthesis of the sakuranetin, an inducible defense mechanism of Oryza sativa against pathogen attack.
 1 Q0IP69