The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 43: RNA polymerase sigma factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
164 P0AGB6 (/IPI) P0AGB6 (/IPI) P0AGB6 (/IPI) P0AGB6 (/IPI) P0AGB6 (/IPI) P0AGB6 (/IPI) P0AGB6 (/IPI) P0AGB6 (/IPI) P0AGB6 (/IPI) P0AGB6 (/IPI)
(154 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
14 Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP)
(4 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
14 Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP)
(4 more)
Sigma factor activity GO:0016987
Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.
14 Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA)
(4 more)
Sigma factor activity GO:0016987
Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.
9 Q9KPA6 (/ISS) Q9KPA6 (/ISS) Q9KPA6 (/ISS) Q9KPA6 (/ISS) Q9KPA6 (/ISS) Q9KPA6 (/ISS) Q9KPA6 (/ISS) Q9KPA6 (/ISS) Q9KPA6 (/ISS)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
164 P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA)
(154 more)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
164 P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA)
(154 more)
Response to temperature stimulus GO:0009266
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
164 P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA)
(154 more)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
129 D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP)
(119 more)
Response to temperature stimulus GO:0009266
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
115 D0ZSY9 (/IEP) D0ZSY9 (/IEP) D0ZSY9 (/IEP) D0ZSY9 (/IEP) D0ZSY9 (/IEP) D0ZSY9 (/IEP) D0ZSY9 (/IEP) D0ZSY9 (/IEP) D0ZSY9 (/IEP) D0ZSY9 (/IEP)
(105 more)
Cellular stress response to acid chemical GO:0097533
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
115 D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP) D0ZSY9 (/IMP)
(105 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
23 Q06198 (/IEP) Q06198 (/IEP) Q06198 (/IEP) Q06198 (/IEP) Q06198 (/IEP) Q06198 (/IEP) Q06198 (/IEP) Q06198 (/IEP) Q06198 (/IEP) Q06198 (/IEP)
(13 more)
Regulation of polysaccharide biosynthetic process GO:0032885
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.
14 Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP)
(4 more)
Cellular response to cell envelope stress GO:0036460
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stress acting at the cell envelope.
14 Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA)
(4 more)
Cellular response to antibiotic GO:0071236
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
14 Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP)
(4 more)
Positive regulation of cellular response to heat GO:1900036
Any process that activates or increases the frequency, rate or extent of cellular response to heat.
14 Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA)
(4 more)
Positive regulation of cell adhesion involved in single-species biofilm formation GO:1900189
Any process that activates or increases the frequency, rate or extent of cell adhesion involved in single-species biofilm formation.
14 Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP)
(4 more)
Positive regulation of single-species biofilm formation on inanimate substrate GO:1900233
Any process that activates or increases the frequency, rate or extent of single-species biofilm formation on inanimate substrate.
14 Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP)
(4 more)
Negative regulation of bacterial-type flagellum-dependent cell motility GO:1902201
Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum-dependent cell motility.
14 Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP)
(4 more)
Positive regulation of response to oxidative stress GO:1902884
Any process that activates or increases the frequency, rate or extent of response to oxidative stress.
14 Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP)
(4 more)
DNA-templated transcription, initiation GO:0006352
Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription.
9 Q9KPA6 (/ISS) Q9KPA6 (/ISS) Q9KPA6 (/ISS) Q9KPA6 (/ISS) Q9KPA6 (/ISS) Q9KPA6 (/ISS) Q9KPA6 (/ISS) Q9KPA6 (/ISS) Q9KPA6 (/ISS)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
164 P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA) P0AGB6 (/IDA)
(154 more)
Cytosolic DNA-directed RNA polymerase complex GO:0000345
The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity.
14 Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA) Q06198 (/IDA)
(4 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
14 Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP) Q06198 (/IMP)
(4 more)