CATH Superfamily 1.10.10.10
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".
FunFam 296: Peroxisomal membrane protein PEX14
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 13 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
6 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
6 | O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) |
|
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
|
6 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) |
|
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
6 | O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) |
|
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
|
6 | O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) O75381 (/IPI) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | A1L567 (/ISS) Q9Z2Z3 (/ISS) |
|
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
2 | A1L567 (/ISS) Q9Z2Z3 (/ISS) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | Q9R0A0 (/ISO) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | Q9R0A0 (/ISO) |
|
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
|
1 | Q9R0A0 (/ISO) |
|
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q9R0A0 (/ISO) |
|
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
|
1 | Q9R0A0 (/ISO) |
There are 33 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein targeting to peroxisome GO:0006625
The process of directing proteins towards the peroxisome, usually using signals contained within the protein.
|
6 | O75381 (/TAS) O75381 (/TAS) O75381 (/TAS) O75381 (/TAS) O75381 (/TAS) O75381 (/TAS) |
|
Peroxisome organization GO:0007031
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
|
6 | O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) |
|
Protein import into peroxisome matrix GO:0016558
The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix.
|
6 | O75381 (/IMP) O75381 (/IMP) O75381 (/IMP) O75381 (/IMP) O75381 (/IMP) O75381 (/IMP) |
|
Protein import into peroxisome matrix, translocation GO:0016561
The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation.
|
6 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
6 | O75381 (/TAS) O75381 (/TAS) O75381 (/TAS) O75381 (/TAS) O75381 (/TAS) O75381 (/TAS) |
|
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
|
6 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) |
|
Microtubule anchoring GO:0034453
Any process in which a microtubule is maintained in a specific location in a cell.
|
6 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) |
|
Peroxisome transport along microtubule GO:0036250
The directed movement of a peroxisome along a microtubule, mediated by motor proteins.
|
6 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
6 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) |
|
Protein import into peroxisome matrix, substrate release GO:0044721
The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane.
|
6 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
6 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) |
|
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
6 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) |
|
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
|
6 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) |
|
Negative regulation of protein homotetramerization GO:1901094
Any process that stops, prevents or reduces the frequency, rate or extent of protein homotetramerization.
|
6 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) |
|
Protein import into peroxisome matrix GO:0016558
The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix.
|
2 | A1L567 (/ISS) Q9Z2Z3 (/ISS) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
2 | A1L567 (/ISS) Q9Z2Z3 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | A1L567 (/ISS) Q9Z2Z3 (/ISS) |
|
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
2 | A1L567 (/ISS) Q9Z2Z3 (/ISS) |
|
Protein targeting to peroxisome GO:0006625
The process of directing proteins towards the peroxisome, usually using signals contained within the protein.
|
1 | Q9VPB8 (/ISS) |
|
Peroxisome organization GO:0007031
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
|
1 | Q642G4 (/IDA) |
|
Peroxisome organization GO:0007031
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
|
1 | Q9VPB8 (/IMP) |
|
Peroxisome organization GO:0007031
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
|
1 | Q9R0A0 (/ISO) |
|
Protein import into peroxisome matrix GO:0016558
The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix.
|
1 | Q9R0A0 (/ISO) |
|
Protein import into peroxisome matrix, translocation GO:0016561
The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation.
|
1 | Q9R0A0 (/ISO) |
|
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
|
1 | Q9R0A0 (/ISO) |
|
Microtubule anchoring GO:0034453
Any process in which a microtubule is maintained in a specific location in a cell.
|
1 | Q9R0A0 (/ISO) |
|
Peroxisome transport along microtubule GO:0036250
The directed movement of a peroxisome along a microtubule, mediated by motor proteins.
|
1 | Q9R0A0 (/ISO) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | Q9R0A0 (/ISO) |
|
Protein import into peroxisome matrix, substrate release GO:0044721
The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane.
|
1 | Q9R0A0 (/ISO) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q9R0A0 (/ISO) |
|
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
1 | Q9R0A0 (/ISO) |
|
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
|
1 | Q9R0A0 (/ISO) |
|
Negative regulation of protein homotetramerization GO:1901094
Any process that stops, prevents or reduces the frequency, rate or extent of protein homotetramerization.
|
1 | Q9R0A0 (/ISO) |
There are 18 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
|
9 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) Q642G4 (/IDA) Q9R0A0 (/IDA) Q9Z2Z3 (/IDA) |
|
Peroxisomal membrane GO:0005778
The lipid bilayer surrounding a peroxisome.
|
8 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) Q642G4 (/IDA) Q9R0A0 (/IDA) |
|
Peroxisomal membrane GO:0005778
The lipid bilayer surrounding a peroxisome.
|
7 | O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) Q9VPB8 (/ISS) |
|
Peroxisomal membrane GO:0005778
The lipid bilayer surrounding a peroxisome.
|
7 | O75381 (/TAS) O75381 (/TAS) O75381 (/TAS) O75381 (/TAS) O75381 (/TAS) O75381 (/TAS) Q642G4 (/TAS) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
7 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) Q642G4 (/IDA) |
|
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
|
6 | O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) O75381 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | O75381 (/NAS) O75381 (/NAS) O75381 (/NAS) O75381 (/NAS) O75381 (/NAS) O75381 (/NAS) |
|
Peroxisomal membrane GO:0005778
The lipid bilayer surrounding a peroxisome.
|
6 | O75381 (/HDA) O75381 (/HDA) O75381 (/HDA) O75381 (/HDA) O75381 (/HDA) O75381 (/HDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
6 | O75381 (/HDA) O75381 (/HDA) O75381 (/HDA) O75381 (/HDA) O75381 (/HDA) O75381 (/HDA) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
6 | O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
6 | O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) O75381 (/ISS) |
|
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
|
5 | A1L567 (/ISS) Q642G4 (/ISS) Q9R0A0 (/ISS) Q9VPB8 (/ISS) Q9Z2Z3 (/ISS) |
|
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
|
1 | Q9R0A0 (/ISO) |
|
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
|
1 | Q9R0A0 (/ISO) |
|
Peroxisomal membrane GO:0005778
The lipid bilayer surrounding a peroxisome.
|
1 | Q9R0A0 (/ISO) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q642G4 (/IDA) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q9R0A0 (/ISO) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q9R0A0 (/ISO) |