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CATH Superfamily 1.10.10.10

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23: Two-component response regulator OmpR

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
 475 P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA)
(465 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 475 P0AA16 (/IPI) P0AA16 (/IPI) P0AA16 (/IPI) P0AA16 (/IPI) P0AA16 (/IPI) P0AA16 (/IPI) P0AA16 (/IPI) P0AA16 (/IPI) P0AA16 (/IPI) P0AA16 (/IPI)
(465 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 45 A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA)
(35 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 45 A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA)
(35 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 45 A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA)
(35 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
 8 Q9KNL8 (/ISS) Q9KNL8 (/ISS) Q9KNL8 (/ISS) Q9KNL8 (/ISS) Q9KNL8 (/ISS) Q9KNL8 (/ISS) Q9KNL8 (/ISS) Q9KNL8 (/ISS)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
 475 P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA)
(465 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 475 P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA) P0AA16 (/IDA)
(465 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 45 A1JSH8 (/EXP) A1JSH8 (/EXP) A1JSH8 (/EXP) A1JSH8 (/EXP) A1JSH8 (/EXP) A1JSH8 (/EXP) A1JSH8 (/EXP) A1JSH8 (/EXP) A1JSH8 (/EXP) A1JSH8 (/EXP)
(35 more)
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
 14 Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP)
(4 more)
Positive regulation of transport GO:0051050
Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
 14 Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP) Q9HTY9 (/IMP)
(4 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
 8 Q9KNL8 (/ISS) Q9KNL8 (/ISS) Q9KNL8 (/ISS) Q9KNL8 (/ISS) Q9KNL8 (/ISS) Q9KNL8 (/ISS) Q9KNL8 (/ISS) Q9KNL8 (/ISS)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 45 A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA) A1JSH8 (/IDA)
(35 more)