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CATH Superfamily 1.10.10.10

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 117: Two-component system response regulator BaeR

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Bacterial-type proximal promoter sequence-specific DNA binding GO:0000986
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a bacterial gene (or cistron, or operon). The proximal promoter is in cis with and relatively close to the core promoter.
 91 P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA)
(81 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 91 P69228 (/IPI) P69228 (/IPI) P69228 (/IPI) P69228 (/IPI) P69228 (/IPI) P69228 (/IPI) P69228 (/IPI) P69228 (/IPI) P69228 (/IPI) P69228 (/IPI)
(81 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 6 P50350 (/IDA) P50350 (/IDA) P50350 (/IDA) P50350 (/IDA) P50350 (/IDA) P50350 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 6 P50350 (/IPI) P50350 (/IPI) P50350 (/IPI) P50350 (/IPI) P50350 (/IPI) P50350 (/IPI)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 6 P50350 (/IDA) P50350 (/IDA) P50350 (/IDA) P50350 (/IDA) P50350 (/IDA) P50350 (/IDA)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 6 P50350 (/IPI) P50350 (/IPI) P50350 (/IPI) P50350 (/IPI) P50350 (/IPI) P50350 (/IPI)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
 91 P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA)
(81 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
 91 P69228 (/IEP) P69228 (/IEP) P69228 (/IEP) P69228 (/IEP) P69228 (/IEP) P69228 (/IEP) P69228 (/IEP) P69228 (/IEP) P69228 (/IEP) P69228 (/IEP)
(81 more)
Positive regulation of DNA-templated transcription, initiation GO:2000144
Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation.
 91 P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA)
(81 more)
Regulation of response to drug GO:2001023
Any process that modulates the frequency, rate or extent of response to drug.
 91 P69228 (/IMP) P69228 (/IMP) P69228 (/IMP) P69228 (/IMP) P69228 (/IMP) P69228 (/IMP) P69228 (/IMP) P69228 (/IMP) P69228 (/IMP) P69228 (/IMP)
(81 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 6 P50350 (/IEP) P50350 (/IEP) P50350 (/IEP) P50350 (/IEP) P50350 (/IEP) P50350 (/IEP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 91 P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA) P69228 (/IDA)
(81 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 6 P50350 (/IDA) P50350 (/IDA) P50350 (/IDA) P50350 (/IDA) P50350 (/IDA) P50350 (/IDA)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 6 P50350 (/IPI) P50350 (/IPI) P50350 (/IPI) P50350 (/IPI) P50350 (/IPI) P50350 (/IPI)