CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Coagulation factor XI

Enzyme Information

3.4.21.27
Coagulation factor XIa.
based on mapping to UniProt P03951
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
-!- The proenzyme XI is activated by EC 3.4.21.38. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P03951
FA11_HUMAN
Homo sapiens
Coagulation factor XI

PDB Structure

PDB 6R8X
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans.
Koch, A.W., Schiering, N., Melkko, S., Ewert, S., Salter, J., Zhang, Y., McCormack, P., Yu, J., Huang, X., Chiu, Y.H., Chen, Z., Schleeger, S., Horny, G., DiPetrillo, K., Muller, L., Hein, A., Villard, F., Scharenberg, M., Ramage, P., Hassiepen, U., Cote, S., DeGagne, J., Krantz, C., Eder, J., Stoll, B., Kulmatycki, K., Feldman, D.L., Hoffmann, P., Basson, C.T., Frost, R.J.A., Khder, Y.
Blood