CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family thymidylate synthase isoform X2

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P04818
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P04818
TYSY_HUMAN
Homo sapiens
Thymidylate synthase

PDB Structure

PDB 6QYQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors.
Pozzi, C., Ferrari, S., Luciani, R., Costi, M.P., Mangani, S.
Molecules