CATH Domain 6o3bH00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.2000	Frizzled cysteine-rich domain
	1.10.2000.10	Frizzled cysteine-rich domain

Domain Context

CATH Clusters

Superfamily	Frizzled cysteine-rich domain
Functional Family	Frizzled class receptor 2

Enzyme Information

UniProtKB Entries (1)

FZD7_HUMAN

Homo sapiens

Frizzled-7

PDB Structure

PDB	6O3B
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Raman, S., Beilschmidt, M., To, M., Lin, K., Lui, F., Jmeian, Y., Ng, M., Fernandez, M., Fu, Y., Mascall, K., Duque, A., Wang, X., Pan, G., Angers, S., Moffat, J., Sidhu, S.S., Magram, J., Sinclair, A.M., Fransson, J., Julien, J.P. Proc. Natl. Acad. Sci. U.S.A.