CATH Classification

Domain Context

CATH Clusters

Superfamily Galactose-binding domain-like
Functional Family Ephrin type-A receptor 2

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P29317
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P29317
EPHA2_HUMAN
Homo sapiens
Ephrin type-A receptor 2

PDB Structure

PDB 6NKP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
Gomez-Soler, M., Petersen Gehring, M., Lechtenberg, B.C., Zapata-Mercado, E., Hristova, K., Pasquale, E.B.
J.Biol.Chem.