CATH Classification
Domain Context
CATH Clusters
| Superfamily | Nitric Oxide Synthase; Chain A, domain 3 |
| Functional Family | Nitric oxide synthase, brain |
Enzyme Information
| 1.14.13.39 |
Nitric-oxide synthase (NADPH).
based on mapping to UniProt P29475
2 L-arginine + 3 NADPH + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O.
-!- The enzyme consists of linked oxygenase and reductase domains. -!- The eukaryotic enzyme binds FAD, FMN, heme (iron protoporphyrin IX) and tetrahydrobiopterin, and its two domains are linked via a regulatory calmodulin-binding domain. -!- Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center. -!- The reductase domain of the enzyme from the bacterium Sorangium cellulosum utilizes a [2Fe-2S] cluster to transfer the electrons from NADPH to the active center. -!- Cf. EC 1.14.14.47.
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UniProtKB Entries (1)
| P29475 |
NOS1_HUMAN
Homo sapiens
Nitric oxide synthase, brain
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PDB Structure
| PDB | 6NGH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.
J. Med. Chem.
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