CATH Classification

Domain Context

CATH Clusters

Superfamily Metalloenzyme, LuxS/M16 peptidase-like
Functional Family Putative insulin-degrading enzyme

Enzyme Information

3.4.24.56
Insulysin.
based on mapping to UniProt P14735
Degradation of insulin, glucagon and other polypeptides. No action on proteins.
-!- Cytosolic enzyme, known from mammals and Drosophila melanogaster. -!- Inhibited by bacitracin, chelating agents EDTA and 1,10- phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. -!- Belongs to peptidase family M16. -!- Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45.

UniProtKB Entries (1)

P14735
IDE_HUMAN
Homo sapiens
Insulin-degrading enzyme

PDB Structure

PDB 6MQ3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.
Maianti, J.P., Tan, G.A., Vetere, A., Welsh, A.J., Wagner, B.K., Seeliger, M.A., Liu, D.R.
Nat.Chem.Biol.