CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.270
Functional Family Gag-Pol polyprotein

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P03355
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.1.-.-
Acting on ester bonds.
based on mapping to UniProt P03355
3.1.26.4
Ribonuclease H.
based on mapping to UniProt P03355
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
2.7.7.-
Nucleotidyltransferases.
based on mapping to UniProt P03355
3.4.23.-
Aspartic endopeptidases.
based on mapping to UniProt P03355
2.7.7.49
RNA-directed DNA polymerase.
based on mapping to UniProt P03355
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.

UniProtKB Entries (1)

P03355
POL_MLVMS
Moloney murine leukemia virus isolate Shinnick
Gag-Pol polyprotein

PDB Structure

PDB 6MIK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Hachimoji DNA and RNA: A genetic system with eight building blocks.
Hoshika, S., Leal, N.A., Kim, M.J., Kim, M.S., Karalkar, N.B., Kim, H.J., Bates, A.M., Watkins Jr., N.E., SantaLucia, H.A., Meyer, A.J., DasGupta, S., Piccirilli, J.A., Ellington, A.D., SantaLucia Jr., J., Georgiadis, M.M., Benner, S.A.
Science