CATH Classification

Domain Context

CATH Clusters

Superfamily MoaB/Mog-like domain
Functional Family Molybdopterin molybdenumtransferase

Enzyme Information

2.7.7.75
Molybdopterin adenylyltransferase.
based on mapping to UniProt Q03555
ATP + molybdopterin = diphosphate + adenylyl-molybdopterin.
-!- Catalyzes the activation of molybdopterin for molybdenum insertion. -!- In eukaryotes, this reaction is catalyzed by the C-terminal domain of a fusion protein that also includes molybdopterin molybdotransferase (EC 2.10.1.1). -!- The reaction requires a divalent cation such as Mg(2+) or Mn(2+). -!- Catalyzes the activation of molybdopterin for molybdenum insertion. -!- In eukaryotes, this reaction is catalyzed by the C-terminal domain of a fusion protein that also includes EC 2.10.1.1. -!- Formerly EC 2.7.7.n5.
2.10.1.1
Molybdopterin molybdotransferase.
based on mapping to UniProt Q03555
Adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.
-!- Catalyzes the insertion of molybdenum into the ene-dithiol group of molybdopterin. -!- In eukaryotes this reaction is catalyzed by the N-terminal domain of a fusion protein whose C-terminal domain catalyzes EC 2.7.7.75.

UniProtKB Entries (1)

Q03555
GEPH_RAT
Rattus norvegicus
Gephyrin

PDB Structure

PDB 6HSO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod, V.B., Hausrat, T.J., Schaefer, N., Kuhn, M., Christensen, N.R., Tessmer, I., Maric, H.M., Madsen, K.L., Sotriffer, C., Villmann, C., Kneussel, M., Schindelin, H.
Neuron