CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.50.150
Functional Family DNA-directed RNA polymerase subunit beta

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P22138
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P10964
RPA1_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerase I subunit RPA190

PDB Structure

PDB 6HLS
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2.
Tafur, L., Sadian, Y., Hanske, J., Wetzel, R., Weis, F., Muller, C.W.
Elife