CATH Classification

Domain Context

CATH Clusters

Superfamily Serine-tRNA synthetase, tRNA binding domain
Functional Family Serine--tRNA ligase

Enzyme Information

6.1.1.11
Serine--tRNA ligase.
based on mapping to UniProt W9BNU9
(1) ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). (2) ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).
-!- This enzyme also recognizes tRNA(Sec), the special tRNA for selenocysteine, and catalyzes the formation of L-seryl-tRNA(Sec), the substrate for EC 2.9.1.1.

UniProtKB Entries (1)

W9BNU9
W9BNU9_KLEPN
Klebsiella pneumoniae
Serine--tRNA ligase

PDB Structure

PDB 6H9X
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily.
De Ruysscher, D., Pang, L., De Graef, S., Nautiyal, M., De Borggraeve, W.M., Rozenski, J., Strelkov, S.V., Weeks, S.D., Van Aerschot, A.
Eur.J.Med.Chem.