CATH Classification

Domain Context

CATH Clusters

Superfamily Fructose-1,6-Bisphosphatase, subunit A, domain 1
Functional Family Inositol-1-monophosphatase

Enzyme Information

3.1.3.94
D-galactose 1-phosphate phosphatase.
based on mapping to UniProt P29218
Alpha-D-galactose 1-phosphate + H(2)O = D-galactose + phosphate.
-!- The human enzyme also has the activity of EC 3.1.3.25. -!- The enzyme has very low activity with L-galactose 1-phosphate (cf. EC 3.1.3.93).
3.1.3.25
Inositol-phosphate phosphatase.
based on mapping to UniProt P29218
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
-!- Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. -!- It also acts on adenosine 2'-phosphate (but not the 3'- or 5'-phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate, but does not act on inositol bisphosphates or more phosphorylated inositols.

UniProtKB Entries (1)

P29218
IMPA1_HUMAN
Homo sapiens
Inositol monophosphatase 1

PDB Structure

PDB 6GJ0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Co-crystallization of human inositol monophosphatase with the lithium mimetic L-690,330.
Kraft, L., Roe, S.M., Gill, R., Atack, J.R.
Acta Crystallogr D Struct Biol