1 keywords

CATH Domain 6g5jB00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.90 Phospholipase A2
Homologous Superfamily 1.20.90.10 Phospholipase A2 domain

Domain Context

CATH Clusters

Superfamily Phospholipase A2 domain
Functional Family Basic phospholipase A2 homolog

Enzyme Information

3.1.1.4
Phospholipase A(2).
based on mapping to UniProt O15496
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
-!- Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.

UniProtKB Entries (1)

O15496
PA2GX_HUMAN
Homo sapiens
Group 10 secretory phospholipase A2

PDB Structure

PDB 6G5J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design of Selective sPLA2-X Inhibitor (-)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1H-indol-1-yl]pyridine-2-yl}propanoic Acid.
Giordanetto, F., Knerr, L., Nordberg, P., Pettersen, D., Selmi, N., Beisel, H.G., de la Motte, H., Mansson, A., Dahlstrom, M., Broddefalk, J., Saarinen, G., Klingegard, F., Hurt-Camejo, E., Rosengren, B., Wikstrom, J., Wagberg, M., Brengdahl, J., Rohman, M., Sandmark, J., Akerud, T., Roth, R.G., Jansen, F., Ahlqvist, M.
ACS Med Chem Lett