CATH Classification

Domain Context

CATH Clusters

Superfamily HUPs
Functional Family Protein FixA homolog

Enzyme Information

1.3.1.108
Caffeoyl-CoA reductase.
based on mapping to UniProt H6LGM7
3-(3,4-dihydroxyphenyl)propanoyl-CoA + 2 NAD(+) + 2 reduced ferredoxin [iron-sulfur] cluster = (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster.
-!- The enzyme, characterized from the bacterium Acetobacterium woodii, couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant. -!- It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction. -!- It also reduces 4-coumaroyl-CoA and feruloyl-CoA.

UniProtKB Entries (1)

H6LGM8
CARE_ACEWD
Acetobacterium woodii DSM 1030
Caffeyl-CoA reductase-Etf complex subunit CarE

PDB Structure

PDB 6FAH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular basis of the flavin-based electron-bifurcating caffeyl-CoA reductase reaction.
Demmer, J.K., Bertsch, J., Oppinger, C., Wohlers, H., Kayastha, K., Demmer, U., Ermler, U., Muller, V.
FEBS Lett.