CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Glucose-6-phosphate 1-dehydrogenase |
Enzyme Information
| 1.1.1.49 |
Glucose-6-phosphate dehydrogenase (NADP(+)).
based on mapping to UniProt P11413
D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH.
-!- The enzyme catalyzes a step of the pentose phosphate pathway. -!- The enzyme is specific for NADP(+), cf. EC 1.1.1.363 and EC 1.1.1.388.
|
UniProtKB Entries (1)
| P11413 |
G6PD_HUMAN
Homo sapiens
Glucose-6-phosphate 1-dehydrogenase
|
PDB Structure
| PDB | 6E08 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator.
Nat Commun
|